ArticleEnvironmental pollution (Barking, Essex : 1987)2019
Urinary metals and leukocyte telomere length in American Indian communities: The Strong Heart and the Strong Heart Family Study.
Article in Environmental pollution (Barking, Essex : 1987), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Role of Glucose Metabolism in the Effects of Serum Metals on Telomere Length: Findings in Chinese Diabetic Population.Biological trace element research · 2025Article
- Dynamic Telomere Length Response to Neurodevelopmental Arsenic Exposure: Insights into Transcriptional Regulation and Neuronal Morphogenesis.Environment & health (Washington, D.C.) · 2025Article
- Associations between metal exposure and metabolic syndrome: exploring the mediating role of biological ageing among US adults.Diabetology & metabolic syndrome · 2025Article
- Physicochemical properties and biological interaction of calcium silicate-based sealers - in vivo model.Clinical oral investigations · 2025Article
- Arsenic and cancer: Evidence and mechanisms.Advances in pharmacology (San Diego, Calif.) · 2023Article
- Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening?Frontiers in public health · 2022Review
- Urinary arsenic and relative telomere length in 5-7 year old children in Bangladesh.Environment international · 2021Article
- Prenatal toxic metal mixture exposure and newborn telomere length: Modification by maternal antioxidant intake.Environmental research · 2020Article
- American Indian chronic Renal insufficiency cohort study (AI-CRIC study).BMC nephrology · 2020Article
- Exposure to arsenic and lead in children from Salamanca México, effects on telomeric lengthening and mitochondrial DNA.Environmental science and pollution research international · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
introductionWhile several mechanisms may explain metal-related health effects, the exact cellular processes are not fully understood. We evaluated the association between leukocyte telomere length (LTL) and urine arsenic (ΣAs), cadmium (Cd) and tungsten (W) exposure in the Strong Heart Study (SHS, N = 1702) and in the Strong Heart Family Study (SHFS, N = 1793).
methodsUrine metal concentrations were measured using ICP-MS. Arsenic exposure was assessed as the sum of inorganic arsenic, monomethylarsonate and dimethylarsinate levels (ΣAs). LTL was measured by quantitative polymerase chain reaction.
resultsIn the SHS, median levels were 1.09 for LTL, and 8.8, 1.01 and 0.11 μg/g creatinine for ΣAs, Cd, and W, respectively. In the SHFS, median levels were 1.01 for LTL, and 4.3, 0.44, and 0.10 μg/g creatinine. Among SHS participants, increased urine ΣAs, Cd, and W was associated with shorter LTL. The adjusted geometric mean ratio (95% confidence interval) of LTL per an increase equal to the difference between the percentiles 90th and 10th in metal distributions was 0.85 (0.79, 0.92) for ΣAs, 0.91 (0.84, 1.00) for Cd and 0.93 (0.88, 0.98) for W. We observed no significant associations among SHFS participants. The findings also suggest that the association between arsenic and LTL might be differential depending on the exposure levels or age.
conclusionsAdditional research is needed to confirm the association between metal exposures and telomere length.
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