Evidence map›Paper›PMID 30557761›Full record

ArticlePsychoneuroendocrinology2019

Chronic stress exposure and daily stress appraisals relate to biological aging marker p16

Kelly E Rentscher, Judith E Carroll, Rena L Repetti, Steve W Cole, Bridget M Reynolds, Theodore F Robles

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 62 citations in OpenAlex.

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  12. Stress-stimulated epinephrine induces premature senescence in dermal fibroblasts and contributes to impaired skin wound healing.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
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  15. Social Support Buffers the Effect of Social Deprivation on Comorbidity Burden in Adults with Cancer.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Kelly E RentscherCousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California, 300 Medical Plaza, Los Angeles, CA 90095, USA. Electronic address: krentscher@ucla.edu.
Judith E CarrollCousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California, 300 Medical Plaza, Los Angeles, CA 90095, USA. Electronic address: JCarroll@mednet.ucla.edu.
Rena L RepettiDepartment of Psychology, University of California, 502 Portola Plaza, Los Angeles, CA 90095, USA. Electronic address: repetti@psych.ucla.edu.
Steve W ColeCousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California, 300 Medical Plaza, Los Angeles, CA 90095, USA. Electronic address: steve.cole@ucla.edu.
Bridget M ReynoldsNational Center for Health Statistics, Centers for Disease Control and Prevention, 3311 Toledo Road, Hyattsville, MD 20782, USA. Electronic address: nnq2@cdc.gov.
Theodore F RoblesCousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California, 300 Medical Plaza, Los Angeles, CA 90095, USA; Department of Psychology, University of California, 502 Portola Plaza, Los Angeles, CA 90095, USA. Electronic address: robles@psych.ucla.edu.
UCLA Medical Center · USUniversity of California, Los Angeles · USCenters for Disease Control and Prevention · USLos Angeles Medical Center · US

Funding

USC/UCLA Center on Biodemography &Population HealthP30AG017265 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, HIRAM BELTRAN-SANCHEZ · 1999 to 2026
$17.9M
Daily life and proinflammatory gene expressionR03HD077387 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROBLES, THEODORE · 2014 to 2015
$152k
NIA NIH HHS P30 AG017265NICHD NIH HHS R03 HD077387
6 · The paper itself

Abstract

Previous research has linked exposure to adverse social conditions with DNA damage and accelerated telomere shortening, raising the possibility that chronic stress may impact biological aging pathways, ultimately increasing risk for age-related diseases. Less clear, however, is whether these stress-related effects extend to additional hallmarks of biological aging, including cellular senescence, a stable state of cell cycle arrest. The present study aimed to investigate associations between psychosocial stress and two markers of cellular aging-leukocyte telomere length (LTL) and cellular senescence signal p16

Indexed as

AdultAgingBiomarkersCellular SenescenceCyclin-Dependent Kinase Inhibitor p16FemaleGenes, p16HumansLeukocytesMaleMiddle AgedSignal TransductionStress, PsychologicalTelomereTelomere ShorteningBiomarkersCyclin-Dependent Kinase Inhibitor p16Biological agingCellular senescenceDaily diaryGene expressionStressTelomere length

Identifiers

PMID30557761
PMCPMC6420375
OpenAlexW2904308212

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.