Evidence map›Paper›PMID 30557692›Full record

ArticleEnvironmental research2019

Relationships between indicators of cardiovascular disease and intensity of oil and natural gas activity in Northeastern Colorado.

Lisa M McKenzie, James Crooks, Jennifer L Peel, Benjamin D Blair, Stephen Brindley, William B Allshouse, Stephanie Malin, John L Adgate

Abstract read
In one paragraph

Article in Environmental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Impact of oil and gas boom and busts on working-age mortality in the U.S.Environmental epidemiology (Philadelphia, Pa.) · 2025
    Article
  5. Article
  6. Article
  7. Sociodemographic and Population Exposure to Upstream Oil and Gas Operations in Canada.International journal of environmental research and public health · 2024
    Article
  8. Article
  9. The human health effects of unconventional oil and gas development (UOGD): A scoping review of epidemiologic studies.Canadian journal of public health = Revue canadienne de sante publique · 2024
    Article
  10. Cardiovascular health and proximity to urban oil drilling in Los Angeles, California.Journal of exposure science & environmental epidemiology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lisa M McKenzieDepartment of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, Aurora, CO, USA. Electronic address: lisa.mckenzie@ucdenver.edu.
James CrooksDivision of Biostatistics and Bioinformatics, National Jewish Health, Denver, CO, USA; Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO, USA.
Jennifer L PeelDepartment of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO, USA; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
Benjamin D BlairDepartment of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, Aurora, CO, USA.
Stephen BrindleyDepartment of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, Aurora, CO, USA.
William B AllshouseDepartment of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, Aurora, CO, USA.
Stephanie MalinDepartment of Sociology & Colorado School of Public Health, Colorado State University, Fort Collins, CO, USA.
John L AdgateDepartment of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, Aurora, CO, USA.
Colorado School of Public Health · US

Funding

Quality of Life and Stress Effects in Communities with Oil and Gas DevelopmentR21ES025140 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI ADGATE, JOHN L. · 2014 to 2015
$426k
NIEHS NIH HHS R21 ES025140
6 · The paper itself

Abstract

backgroundOil and natural gas (O&G) extraction emits pollutants that are associated with cardiovascular disease, the leading cause of mortality in the United States.

objectiveWe evaluated associations between intensity of O&G activity and cardiovascular disease indicators.

methodsBetween October 2015 and May 2016, we conducted a cross-sectional study of 97 adults living in Northeastern Colorado. For each participant, we collected 1-3 measurements of augmentation index, systolic and diastolic blood pressure (SBP and DBP), and plasma concentrations of interleukin (IL)- 1β, IL-6, IL-8 and tumor necrosis factor alpha (TNF-α). We modelled the intensity of O&G activity by weighting O&G well counts within 16 km of a participant's home by intensity and distance. We used linear models accounting for repeated measures within person to evaluate associations.

resultsAdjusted mean augmentation index differed by 6.0% (95% CI: 0.6, 11.4%) and 5.1% (95%CI: -0.1, 10.4%) between high and medium, respectively, and low exposure tertiles. The greatest mean IL-1β, and α-TNF plasma concentrations were observed for participants in the highest exposure tertile. IL-6 and IL-8 results were consistent with a null result. For participants not taking prescription medications, the adjusted mean SBP differed by 6 and 1 mm Hg (95% CIs: 0.1, 13 mm Hg and -6, 8 mm Hg) between the high and medium, respectively, and low exposure tertiles. DBP results were similar. For participants taking prescription medications, SBP and DBP results were consistent with a null result.

conclusionsDespite limitations, our results support associations between O&G activity and augmentation index, SBP, DBP, IL-1β, and TNF-α. Our study was not able to elucidate possible mechanisms or environmental stressors, such as air pollution and noise.

Indexed as

HypertensionOil and Gas FieldsAdultBlood PressureCardiovascular DiseasesColoradoCross-Sectional StudiesEnvironmental ExposureFemaleHumansIndicators and ReagentsNatural GasUnited StatesIndicators and ReagentsNatural Gas

Identifiers

PMID30557692
PMCPMC6360130
OpenAlexW2905230627

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.