Evidence map›Paper›PMID 30557635›Full record

ArticleBone2019

Body composition and bone mineral density in childhood.

Lisa B Rokoff, Sheryl L Rifas-Shiman, Karen M Switkowski, Jessica G Young, Clifford J Rosen, Emily Oken, Abby F Fleisch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lisa B RokoffDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA. Electronic address: lrokoff@mail.harvard.edu.
Sheryl L Rifas-ShimanDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Karen M SwitkowskiDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Jessica G YoungDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Clifford J RosenCenter for Clinical and Translational Research, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, ME, USA.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Abby F FleischPediatric Endocrinology and Diabetes, Maine Medical Center, Portland, ME, USA; Center for Outcomes Research and Evaluation, Maine Medical Center Research Institute, Portland, ME, USA.

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUG3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI KLEINMAN, KENNETH P., OKEN, EMILY · 2016 to 2017
$4.1M
Patient-oriented Research in Maternal Perinatal Overnutrition and Child AdiposityK24HD069408 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2011 to 2015
$844k
Air Pollution Exposure during Pregnancy, Maternal Glycemia, and OffspringGrowthK23ES024803 · NIEHS · MAINEHEALTH · PI FLEISCH, ABBY · 2015 to 2019
$835k
NICHD NIH HHS K24 HD069408NICHD NIH HHS R01 HD034568NIEHS NIH HHS K23 ES024803NIH HHS UG3 OD023286NIH HHS UH3 OD023286
6 · The paper itself

Abstract

backgroundBody mass compartments may have different directions of influence on bone accrual. Studies of children are limited by relatively small sample sizes and typically make strong assumptions of linear regression.

objectiveTo evaluate associations of overall body mass, components of overall body mass (fat-free and total fat), and components of total fat mass (truncal and non-truncal fat), measured via dual-energy X-ray absorptiometry (DXA) and anthropometry, with total body less head areal bone mineral density (aBMD) Z-score in mid-childhood.

methodsWe performed a cross-sectional study among 876 Boston-area children who had DXA measures. We evaluated linearity of associations using generalized additive models.

resultsChildren were median 7.7 (range 6-10) years of age, and 61% were white. After adjustment for sociodemographics and other compartments of body mass, overall body mass, particularly the fat-free mass component, appeared to have a positive relationship with aBMD Z-score [e.g., 0.25 (95% CI: 0.23, 0.28) per 1-kg fat-free mass]. The relationship between truncal fat and aBMD Z-score appeared non-linear, with a negative association only in children with levels of fat mass in the upper 15th percentile [-0.17 (95% CI: -0.26, -0.07) aBMD Z-score per 1-kg truncal fat mass], while non-truncal fat mass was not associated with aBMD Z-score.

conclusionsOur analyses suggest that central adiposity is associated with lower aBMD Z-score only in children with the highest levels of abdominal fat. This finding raises the possibility of a threshold above which central adipose tissue becomes more metabolically active and thereby adversely impacts bone.

Indexed as

Absorptiometry, PhotonAdipose TissueAdiposityAnthropometryBody CompositionBone DensityChildCross-Sectional StudiesFemaleHumansMaleAdiposityAreal bone mineral densityBody compositionDual-energy X-ray absorptiometry

Identifiers

PMID30557635
PMCPMC6391186

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.