Evidence map›Paper›PMID 30557566›Full record

ArticleNeuropharmacology2019

Brain-derived neurotrophic factor signaling mitigates the impact of acute social stress.

Anna M Rosenhauer, Linda Q Beach, Elizabeth C Jeffress, Brittany M Thompson, Katharine E McCann, Katherine A Partrick, Bryan Diaz, Alisa Norvelle, Dennis C Choi, Kim L Huhman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. BDNF Therapeutic Mechanisms in Neuropsychiatric Disorders.International journal of molecular sciences · 2022
    Review
  6. Molecular and neurocircuitry mechanisms of social avoidance.Cellular and molecular life sciences : CMLS · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Anna M RosenhauerNeuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30303, United States.
Linda Q BeachNeuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30303, United States.
Elizabeth C JeffressNeuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30303, United States.
Brittany M ThompsonNeuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30303, United States.
Katharine E McCannNeuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30303, United States.
Katherine A PartrickNeuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30303, United States.
Bryan DiazNeuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30303, United States.
Alisa NorvelleNeuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30303, United States.
Dennis C ChoiNeuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30303, United States.
Kim L HuhmanNeuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30303, United States. Electronic address: khuhman@gsu.edu.
Georgia State University · US

Funding

Neurobiology of Social BehaviorR01MH062044 · NIMH · GEORGIA STATE UNIVERSITY · PI HUHMAN, KIM L · 2002 to 2017
$4.5M
NIMH NIH HHS R01 MH062044
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) is known to promote fear learning as well as avoidant behavioral responses to chronic social defeat stress, but, conversely, this peptide can also have antidepressant effects and can reduce depressant-like symptoms such as social avoidance. The purpose of this study was to use a variety of approaches to determine whether BDNF acting on tropomyosin receptor kinase B (TrkB) promotes or prevents avoidant phenotypes in hamsters and mice that have experienced acute social defeat stress. We utilized systemic and brain region-dependent manipulation of BDNF signaling before or immediately following social defeat stress in Syrian hamsters, TrkB

Indexed as

Social BehaviorAnimalsAvoidance LearningBasolateral Nuclear ComplexBrain-Derived Neurotrophic FactorCricetinaeGene Knockdown TechniquesGene Knock-In TechniquesMaleMembrane GlycoproteinsMiceMicroinjectionsNucleus AccumbensProtein-Tyrosine KinasesReceptor, trkBStress, PsychologicalBrain-Derived Neurotrophic FactorMembrane GlycoproteinsNtrk2 protein, mouseProtein-Tyrosine KinasesReceptor, trkBBasolateral amygdalaConditioned defeatNucleus accumbensSocial avoidanceSocial defeatTrkB

Identifiers

PMID30557566
PMCPMC6424638
OpenAlexW2903932051

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.