ArticleAnnals of internal medicine2019
Long-Term Outcomes Among Patients Discharged From the Hospital With Moderate Anemia: A Retrospective Cohort Study.
Article in Annals of internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The use of iron after surgery: a systematic review and meta-analysis.Anaesthesia · 2025Pooled it
- Association between peri-operative red blood cell transfusion and cancer recurrence in patients undergoing major cancer surgery: an umbrella review.Anaesthesia · 2025Pooled it
- Potential benefits of restrictive transfusion in upper gastrointestinal bleeding: a systematic review and meta-analysis of randomised controlled trials.Scientific reports · 2023Pooled it
- Practical Anemia Bundle and Hemoglobin Recovery in Critical Illness: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Preoperative intravenous iron for anaemia in elective major open abdominal surgery: the PREVENTT RCT.Health technology assessment (Winchester, England) · 2021Trial
- Feasibility of Activity Monitors to Assess Physical Capacity After Critical Illness: An Observational Study Nested Within a Randomized Clinical Trial.Mayo Clinic proceedings. Digital health · 2026Article
- Profound anemia in hospitalized community acquired pneumonia patients is associated with increased mortality and is prevalent in all patients' age-groups. a retrospective analysis of 15,121 patients.BMC infectious diseases · 2025Article
- Postoperative anemia: prevention without cure is not enough.Blood transfusion = Trasfusione del sangue · 2025Article
- Consensus of the Brazilian association of hematology, hemotherapy and cellular therapy on patient blood management: Assessment and management of postoperative anemia.Hematology, transfusion and cell therapy · 2024Article
- Haemoglobin thresholds to define anaemia from age 6 months to 65 years: estimates from international data sources.The Lancet. Haematology · 2024Article
- Ultra-restrictive red blood cell transfusion strategies in extensively burned patients.Scientific reports · 2024Article
- IntravenousBMJ open · 2023Article
- Association between anaemia and hospital readmissions in patients undergoing major surgery requiring postoperative intensive care.Anaesthesia · 2023Article
- Week-One Anaemia was Associated with Increased One-Year Mortality in Critically Ill Surgical Patients.International journal of clinical practice · 2022Article
- Predicting Prognosis in Internal Medicine: A Short and Long-Term Mortality Comparison Analysis.Cureus · 2022Article
- Hematinic and Iron Optimization in Peri-operative Anemia and Iron Deficiency.Current anesthesiology reports · 2022Review
- Impact of in-hospital intravenous iron supplementation on red blood cell transfusions: experience from an Internal Medicine Unit.Blood transfusion = Trasfusione del sangue · 2021Observational
- Impact of gender parity on preoperative anaemia prevalence and Patient Blood Management practice.Blood transfusion = Trasfusione del sangue · 2021Article
- Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearance.iScience · 2021Article
- The Importance of Iron Administration in Correcting Anaemia After Major Surgery.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2021Article
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10 authors.
Funding
Abstract
Background: Randomized clinical trial findings support decreased red blood cell (RBC) transfusion and short-term tolerance of in-hospital anemia. However, long-term outcomes related to changes in transfusion practice have not been described. Objective: To describe the prevalence of anemia at and after hospital discharge and associated morbidity and mortality events. Design: Retrospective cohort study. Setting: Integrated health care delivery system with 21 hospitals serving 4 million members. Participants: 445 371 surviving adults who had 801 261 hospitalizations between January 2010 and December 2014. Measurements: Hemoglobin levels and RBC transfusion, rehospitalization, and mortality events within 6 months of hospital discharge. Generalized estimating equations were used to examine trends over time, accounting for correlated observations and patient-level covariates. Results: From 2010 to 2014, the prevalence of moderate anemia (hemoglobin levels between 7 and 10 g/dL) at hospital discharge increased from 20% to 25% (P < 0.001) and RBC transfusion declined by 28% (39.8 to 28.5 RBC units per 1000 patients; P < 0.001). The proportion of patients whose moderate anemia had resolved within 6 months of hospital discharge decreased from 42% to 34% (P < 0.001), and RBC transfusion and rehospitalization within 6 months of hospital discharge decreased from 19% to 17% and 37% to 33%, respectively (P < 0.001 for both). During this period, the adjusted 6-month mortality rate decreased from 16.1% to 15.6% (P = 0.004) in patients with moderate anemia, in parallel with that of all others. Limitation: Possible unmeasured confounding. Conclusion: Anemia after hospitalization increased in parallel with decreased RBC transfusion. This increase was not accompanied by a rise in subsequent RBC use, rehospitalization, or mortality within 6 months of hospital discharge. Longitudinal analyses support the safety of practice recommendations to limit RBC transfusion and tolerate anemia during and after hospitalization. Primary Funding Source: National Heart, Lung, and Blood Institute.
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