ArticlePloS one2018
Exposure to phthalates aggravates pulmonary function and airway inflammation in asthmatic children.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 51 citations in OpenAlex.
- Association of Childhood Asthma with the Concept of Exposomics: A Short Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Antioxidant Potential of Gallic Acid Prevents Di-2-ethyhexyl Phthalate-induced Inhibition of Osteogenic Differentiation.Current drug metabolism · 2025Article
- Article
- Repeated Human Exposure to Semivolatile Organic Compounds by Inhalation: Novel Protocol for a Nonrandomized Study.JMIR research protocols · 2023Article
- Lifestyle practices that reduce seasonal PMScientific reports · 2023Article
- Association of Metabolites, Nutrients, and Toxins in Maternal and Cord Serum with Asthma, IgE, SPT, FeNO, and Lung Function in Offspring.Metabolites · 2023Article
- A cross sectional pilot study to assess the role of phthalates on respiratory morbidity among patients with chronic obstructive pulmonary disease.Environmental research · 2023Article
- Characterizing changes in behaviors associated with chemical exposures during the COVID-19 pandemic.PloS one · 2023Article
- Personal air pollutant exposure monitoring in South African children in the VHEMBE birth cohort.Environment international · 2022Article
- Phthalate biomarkers and associations with respiratory symptoms and healthcare utilization among low-income urban children with asthma.Environmental research · 2022Article
- The Detrimental Effects of Phthalates on Allergic Diseases.Allergy, asthma & immunology research · 2022Article
- Dietary correlates of urinary phthalate metabolite concentrations in 6-19 Year old children and adolescents.Environmental research · 2022Article
- Integrated Genomic and Bioinformatics Approaches to Identify Molecular Links between Endocrine Disruptors and Adverse Outcomes.International journal of environmental research and public health · 2022Review
- Endocrine-Disrupting Chemicals and Infectious Diseases: From Endocrine Disruption to Immunosuppression.International journal of molecular sciences · 2021Review
- Transdermal uptake of benzophenone-3 from clothing: comparison of human participant results to model predictions.Journal of exposure science & environmental epidemiology · 2021Article
- IL-22/IL-22R1 promotes proliferation and collagen synthesis of MRC-5 cells via the JAK/STAT3 signaling pathway and regulates airway subepithelial fibrosis.Experimental and therapeutic medicine · 2020Article
- Fine Particulate Matter and Gaseous Compounds in Kitchens and Outdoor Air of Different Dwellings.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionStudies on the associations between phthalate exposures and respiratory outcomes are limited. We investigated the association of phthalates exposure with pulmonary function and airway inflammation in asthmatic children.
methodsFifty-six children with asthma living in Seoul Metropolitan Area, Korea aged 6-16 years were enrolled. Their pulmonary function including forced expiratory volume in 1 sec (FEV1) and peak expiratory flow rate (PEFR) were measured, and the fractional exhaled nitric oxide (FeNO) as a marker of airway inflammation was examined repeatedly up to four times during the study period. Urinary levels of mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), metabolites for di-(2-ethylhexyl) phthalate (DEHP), and mono-n-butyl phthalate (MnBP), a metabolite of di-n-butyl phthalate (DnBP), were also measured on the same days. The effects of phthalate metabolites on the respiratory symptoms were analyzed using linear mixed effect models with adjustment for potential cofounders.
resultsAn increase in phthalate metabolites was associated with a decrease in pulmonary function and an increase in FeNO in asthmatic children. As one natural log-unit (ln-unit) levels of urinary MEHHP and MEOHP increased, FeNO levels on the same day increased by 19.47 ppb [95% confidence interval (CI): 9.28, 29.67] and 17.93 ppb (95% CI: 5.86, 30.01), respectively. An increases in the urinary level of MEHHP, MEOHP, and MnBP by one ln-unit was associated with a decrease in PEFR on the next day by 12.17 L/min (95% CI: 2.59, 21.74), 10.80 L/min (95% CI: 0.29, 21.32), and 13.65 L/min (95% CI: 5.07, 22.24), respectively.
conclusionPhthalates, especially DEHP, may worsen pulmonary function and airway inflammation in asthmatic children. To control asthma symptoms, exposure to phthalates needs to be avoided.
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