Evidence map›Paper›PMID 30557150›Full record

ReviewAlcohol research : current reviews2018

Binge Drinking's Effects on the Developing Brain-Animal Models.

Susanne Hiller-Sturmhöfel, Linda Patia Spear

Open access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in Alcohol research : current reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Susanne Hiller-SturmhöfelSusanne Hiller-Sturmhöfel, Ph.D., is a science writer and editor affiliated with CSR Inc., Arlington, Virginia. Linda Patia Spear, Ph.D., is a distinguished professor, Department of Psychology, State University of New York, and the director of the Developmental Exposure Alcohol Research Center, Binghamton University, Binghamton, New York.
Linda Patia SpearSusanne Hiller-Sturmhöfel, Ph.D., is a science writer and editor affiliated with CSR Inc., Arlington, Virginia. Linda Patia Spear, Ph.D., is a distinguished professor, Department of Psychology, State University of New York, and the director of the Developmental Exposure Alcohol Research Center, Binghamton University, Binghamton, New York.
Binghamton University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adolescence typically is a time of experimentation, including alcohol use and, particularly, binge drinking. Because the brain is still developing during adolescence, such exposure could have long-lasting effects. Animal models and adolescent intermittent ethanol exposure (AIE) paradigms have been used to help elucidate the consequences of adolescent binge drinking. These studies have identified cognitive deficits, particularly in challenging cognitive tasks, and behavioral alterations such as greater risk preferences, impulsivity, and disinhibition. AIE also is associated with changes in affect when the animals reach adulthood, including increased social anxiety and, sometimes, general anxiety. Animal models have demonstrated that AIE can result in retention of certain alcohol-related adolescent phenotypes (i.e., reduced sensitivity to alcohol's aversive effects and increased sensitivity to alcohol's rewarding effects) into adulthood, which may motivate continued elevated alcohol use. The detrimental effects of adolescent alcohol exposure extend to a diversity of lasting alterations in the brain, including reduced neurogenesis, increased proinflammatory responses, changes in gene expression through epigenetic mechanisms, and alterations in the activities of various neurotransmitter systems. Further exploration of these mechanisms in animal models and humans may lead to improved prevention and intervention efforts.

Indexed as

AlcoholismBinge DrinkingBrainDisease Models, AnimalAnimals

Identifiers

PMID30557150
PMCPMC6104958
OpenAlexW2949374787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.