Evidence map›Paper›PMID 30556932›Full record

ArticleNMR in biomedicine2019

Three-dimensional echo planar spectroscopic imaging for differentiation of true progression from pseudoprogression in patients with glioblastoma.

Gaurav Verma, Sanjeev Chawla, Suyash Mohan, Sumei Wang, MacLean Nasrallah, Sulaiman Sheriff, Arati Desai, Steven Brem, Donald M O'Rourke, Ronald L Wolf and 2 more

Abstract read
In one paragraph

Article in NMR in biomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  19. HyperpolarizedScientific reports · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gaurav VermaDepartment of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Sanjeev ChawlaDepartment of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Suyash MohanDepartment of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Sumei WangDepartment of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
MacLean NasrallahDepartment of Pathology and Lab Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Sulaiman SheriffDepartment of Radiology, University of Miami, Miami, FL, USA.
Arati DesaiDepartment of Hematology-Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Steven BremDepartment of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Donald M O'RourkeDepartment of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Ronald L WolfDepartment of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Andrew A MaudsleyDepartment of Radiology, University of Miami, Miami, FL, USA.ORCID 0000-0001-7653-3063
Harish PoptaniDepartment of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-0593-3235

Funding

NIH Clinical Center 1R21CA170284 (HP)NIH Clinical Center R01EB016064 (AAM)
6 · The paper itself

Abstract

Accurate differentiation of true progression (TP) from pseudoprogression (PsP) in patients with glioblastomas (GBMs) is essential for planning adequate treatment and for estimating clinical outcome measures and future prognosis. The purpose of this study was to investigate the utility of three-dimensional echo planar spectroscopic imaging (3D-EPSI) in distinguishing TP from PsP in GBM patients. For this institutional review board approved and HIPAA compliant retrospective study, 27 patients with GBM demonstrating enhancing lesions within six months of completion of concurrent chemo-radiation therapy were included. Of these, 18 were subsequently classified as TP and 9 as PsP based on histological features or follow-up MRI studies. Parametric maps of choline/creatine (Cho/Cr) and choline/N-acetylaspartate (Cho/NAA) were computed and co-registered with post-contrast T

Indexed as

Disease ProgressionEcho-Planar ImagingArea Under CurveFemaleGlioblastomaHumansLogistic ModelsMaleMetabolomeMiddle AgedProton Magnetic Resonance SpectroscopyROC Curveecho planar spectroscopic imagingglioblastomaproton MRSpseudoprogressiontrue progressiontumor treatment response

Identifiers

PMID30556932
PMCPMC6519064

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.