Evidence map›Paper›PMID 30556913›Full record

Trial reportAlcoholism, clinical and experimental research2019

Elucidating the Effect of a Brief Drinking Intervention Using Neuroimaging: A Preliminary Study.

Erica N Grodin, Lara A Ray, James MacKillop, Aaron C Lim, Mitchell P Karno

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alcoholism, clinical and experimental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04710095 (Perceived Alcohol Reward Value and Risk), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04710095 nacompletednot on this map

Perceived Alcohol Reward Value and Risk: Neural Correlates and Treatment Effects

TypeinterventionalSponsorUniversity of California, Los AngelesRan2015 to 2017Enrolled60ConditionsHeavy DrinkingArmsBrief Alcohol Intervention, Control Condition
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Effect of alcohol, tobacco, and cannabis co-use on gray matter volume in heavy drinkers.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2021
    Article
  3. Article
  4. Article
  5. Precuneus: A Key on the Road to Translation.Alcoholism, clinical and experimental research · 2019
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Erica N GrodinDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0001-5528-4918
Lara A RayDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0002-5734-9444
James MacKillopDepartment of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada.
Aaron C LimDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.
Mitchell P KarnoDepartment of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, University of California, Los Angeles, Los Angeles, California.
University of California, Los Angeles · USMcMaster University · CA

Funding

UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
UCLA DRUG ABUSE RESEARCH TRAINING PROGRAMT32DA007272 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRELLA, CHRISTINE E · 1991 to 2017
$4.9M
Clinical Neuroscience of Alcoholism: Integrating Neuroscience and Clinical TrialsK24AA025704 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY · 2018 to 2026
$1.3M
Perceived alcohol reward value and risk: Neural correlates and treatment effectsR21AA023669 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KARNO, MITCHELL P, RAY, LARA A. · 2015 to 2016
$344k
NIAAA NIH HHS K24 AA025704NIAAA NIH HHS R21 AA023669NIDA NIH HHS T32 DA007272NIDA NIH HHS T32 DA024635
6 · The paper itself

Abstract

backgroundBrief interventions have empirical support for acutely reducing alcohol use among non-treatment-seeking heavy drinkers. Neuroimaging techniques allow for the examination of the neurobiological effect of behavioral interventions, probing brain systems putatively involved in clinical response to treatment. Few studies have prospectively evaluated whether psychosocial interventions attenuate neural cue reactivity that in turn reduces drinking in the same population. This study aimed to examine the effect of a brief intervention on drinking outcomes, neural alcohol cue reactivity, and the ability of neural alcohol cue reactivity to prospectively predict drinking outcomes.

methodsNon-treatment-seeking heavy drinking participants were randomized to receive a brief interview intervention (n = 22) or an attention-matched control (n = 24). Immediately following the intervention or control, participants underwent a functional magnetic resonance imaging scan comprised of the alcohol taste cues paradigm. Four weeks after the intervention (or control), participants completed a follow-up visit to report on their past-month drinking. Baseline and follow-up percent heavy drinking days (PHDD) were calculated for each participant.

resultsThere was no significant effect of the brief intervention on PHDD at follow-up or on modulating neural activation to alcohol relative to water taste cues. There was a significant association between neural response to alcohol taste cues and PHDD across groups (Z > 2.3, p < 0.05), such that individuals who had greater neural reactivity to alcohol taste cues in the precuneus and prefrontal cortex (PFC) had fewer PHDD at follow-up.

conclusionsThis study did not find an effect of the brief intervention on alcohol use in this sample, and the intervention was not associated with differential neural alcohol cue reactivity. Nevertheless, greater activation of the precuneus and PFC during alcohol cue exposure predicted less alcohol use prospectively suggesting that these neural substrates subserve the effects of alcohol cues on drinking behavior.

Indexed as

Motivational InterviewingPsychotherapy, BriefAdultAlcohol DrinkingCuesFemaleFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleParietal LobePrefrontal CortexTaste PerceptionYoung AdultAlcoholBrief InterventionfMRIMechanisms of Behavior ChangePrecuneus

Identifiers

PMID30556913
PMCPMC6370530
OpenAlexW2904543139

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.