Evidence map›Paper›PMID 30556808›Full record

ArticleeLife2018

Shed EBA-175 mediates red blood cell clustering that enhances malaria parasite growth and enables immune evasion.

May M Paing, Nichole D Salinas, Yvonne Adams, Anna Oksman, Anja Tr Jensen, Daniel E Goldberg, Niraj H Tolia

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. bioRxiv : the preprint server for biology · 2025
    Article
  3. Malaria: past, present, and future.Signal transduction and targeted therapy · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. γδ T Cells KillJournal of immunology (Baltimore, Md. : 1950) · 2020
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

May M Paing *Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, United States.
Nichole D Salinas *Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, United States.
Yvonne AdamsCentre for Medical Parasitology at Department of Immunology and Microbiology (ISIM), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Anna OksmanDepartment of Medicine, Washington University School of Medicine, St. Louis, United States.
Anja Tr JensenCentre for Medical Parasitology at Department of Immunology and Microbiology (ISIM), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-4004-7554
Daniel E GoldbergDepartment of Medicine, Washington University School of Medicine, St. Louis, United States.ORCID http://orcid.org/0000-0003-3529-8399
Niraj H ToliaDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, United States.ORCID http://orcid.org/0000-0002-2689-1337

Funding

Viral Discovery in Rheumatoid ArthritisP30AR048335 · NIAMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 2001 to 2015
$8.9M
Structural characterization of host-pathogen interactionsZIAAI001237 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI TOLIA, NIRAJ · 2018 to 2025
$6.6M
Structural Vaccinology and Design of Novel Imunogens for Malaria Vaccine DevelopmentR01AI137162 · NIAID · WASHINGTON UNIVERSITY · PI GOLDBERG, DANIEL E. · 2018 to 2022
$3.6M
ELUCIDATING & DISRUPTING PLASMODIUM ERYTHROCYTE-BINDING LIKE LIGAND INTERACTIONSR01AI080792 · NIAID · WASHINGTON UNIVERSITY · PI TOLIA, NIRAJ H. · 2009 to 2013
$1.9M
ELUCIDATING & DISRUPTING PLASMODIUM RECEPTOR-LIGAND INTERACTIONSR56AI080792 · NIAID · WASHINGTON UNIVERSITY · PI TOLIA, NIRAJ H. · 2015 to 2015
$381k
NIAID NIH HHS Extramural Research Program AI080792NIAID NIH HHS Intramural Research ProgramNIAID NIH HHS R01 AI080792NIAID NIH HHS R01 AI137162NIAID NIH HHS R56 AI080792NIAMS NIH HHS P30 AR048335Wellcome TrustWellcome Trust 097945/B/11/Z
6 · The paper itself

Abstract

Erythrocyte Binding Antigen of 175 kDa (EBA-175) has a well-defined role in binding to glycophorin A (GpA) during

Indexed as

Immune EvasionAntibodies, NeutralizingAntigens, ProtozoanCarrier ProteinsCell AggregationCells, CulturedCulture Media, ConditionedErythrocytesGene ExpressionGlycophorinsHumansMembrane ProteinsMerozoitesPlasmodium falciparumProtein BindingProtozoan ProteinsAntibodies, NeutralizingAntigens, Protozoanapical membrane antigen I, PlasmodiumCarrier ProteinsCulture Media, Conditionederythrocyte-binding antigen 175, PlasmodiumGlycophorinsMembrane ProteinsProtozoan ProteinsRH5 protein, Plasmodium falciparumantibodyevasiongrowthinfectious diseasemalariamicrobiologyP. falciparum

Identifiers

PMID30556808
PMCPMC6305201

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.