Evidence map›Paper›PMID 30556762›Full record

ReviewTranscription2019

RNA processing in skeletal muscle biology and disease.

Emma R Hinkle, Hannah J Wiedner, Adam J Black, Jimena Giudice

Abstract readReview
In one paragraph

Review in Transcription, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Epigenetic control of skeletal muscle atrophy.Cellular & molecular biology letters · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Overexpression of theAnimals : an open access journal from MDPI · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Emma R Hinklea Curriculum in Genetics and Molecular Biology (GMB) , University of North Carolina , Chapel Hill , USA.ORCID 0000-0002-7396-7525
Hannah J Wiednera Curriculum in Genetics and Molecular Biology (GMB) , University of North Carolina , Chapel Hill , USA.ORCID 0000-0002-5919-5944
Adam J Blackb Department of Cell Biology & Physiology , University of North Carolina , Chapel Hill , USA.ORCID 0000-0002-5205-3513
Jimena Giudicea Curriculum in Genetics and Molecular Biology (GMB) , University of North Carolina , Chapel Hill , USA.ORCID 0000-0002-3330-7784

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
Training in Mechanistic, Interdisciplinary Studies of Biological SystemsT32GM119999 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAMSDEN, DALE A · 2017 to 2021
$1.2M
NCATS NIH HHS UL1 TR002489NIDDK NIH HHS P30 DK056350NIGMS NIH HHS T32 GM007092NIGMS NIH HHS T32 GM119999
6 · The paper itself

Abstract

RNA processing encompasses the capping, cleavage, polyadenylation and alternative splicing of pre-mRNA. Proper muscle development relies on precise RNA processing, driven by the coordination between RNA-binding proteins. Recently, skeletal muscle biology has been intensely investigated in terms of RNA processing. High throughput studies paired with deletion of RNA-binding proteins have provided a high-level understanding of the molecular mechanisms controlling the regulation of RNA-processing in skeletal muscle. Furthermore, misregulation of RNA processing is implicated in muscle diseases. In this review, we comprehensively summarize recent studies in skeletal muscle that demonstrated: (i) the importance of RNA processing, (ii) the RNA-binding proteins that are involved, and (iii) diseases associated with defects in RNA processing.

Indexed as

Models, GeneticRNA Processing, Post-TranscriptionalEpigenesis, GeneticHumansMuscle, SkeletalMuscular Diseasesalternative splicingepigeneticsRNA processingskeletal muscletranscription

Identifiers

PMID30556762
PMCPMC6351125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.