ArticleOruen : the CNS journal2017
Dissection method affects electrophysiological properties of hippocampal slices.
Article in Oruen : the CNS journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- The herbicide glyphosate inhibits hippocampal long-term potentiation and learning through activation of pro-inflammatory signaling.Scientific reports · 2023Article
- Metabolic Changes in Brain Slices over Time: a Multiplatform Metabolomics Approach.Molecular neurobiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The rodent hippocampal slice preparation has long been a critical tool for studying the electrophysiological effects of pharmacological and genetic manipulations. Slices can be prepared with several different slicing methods including the tissue chopper, vibratome, and rotary slicer. To examine how slicing methods affect slice integrity, we generated hippocampal slices by these three methods and compared their histology and electrophysiological responses. Although all three methods generate histological alterations, the time course is slowest in slices generated with a rotary slicer. Furthermore, although paired-pulse facilitation in dendritic field EPSPs was observed in slices generated by all three methods, paired-pulse potentiation in population spikes, which is common in chopper- and vibratome-generated slices was seldom observed in rotary-generated slices, suggesting less disinhibiton. For preservation of hippocampal slice integrity, the rotary slicer may offer advantages over the other two devices.
Indexed as
Identifiers
30556063PMC6292686W2997786481What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.