Evidence map›Paper›PMID 30556046›Full record

ArticleAPL bioengineering2018

The Extracellular Matrix of Ovarian Cortical Inclusion Cysts Modulates Invasion of Fallopian Tube Epithelial Cells.

Andrew J Fleszar, Alyssa Walker, Veronica Porubsky, Will Flanigan, Darian James, Paul J Campagnola, Paul S Weisman, Pamela K Kreeger

Open access · goldAbstract read
In one paragraph

Article in APL bioengineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Molecular Management of High-Grade Serous Ovarian Carcinoma.International journal of molecular sciences · 2022
    Review
  12. Article
  13. Bioengineering Approaches to Improve Gynecological Cancer Outcomes.Current opinion in biomedical engineering · 2022
    Article
  14. Review
  15. Multi-modal Profiling of the Extracellular Matrix of Human Fallopian Tubes and Serous Tubal Intraepithelial Carcinomas.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022
    Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Bioengineering models of female reproduction.Bio-design and manufacturing · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Andrew J FleszarDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Alyssa WalkerDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Veronica PorubskyDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Will FlaniganDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Darian JamesDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Paul J CampagnolaDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Paul S WeismanDepartment of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA.
Pamela K KreegerDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
Analysis of how quantitative cellular network variation impacts tumor progressionDP2CA195766 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KREEGER, PAMELA K · 2014 to 2014
$2.3M
Quantitative assessment of the role of collagen alterations in ovarian cancerR01CA206561 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAMPAGNOLA, PAUL J, ELICEIRI, KEVIN WILLIAM · 2016 to 2020
$2.1M
NCI NIH HHS DP2 CA195766NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA206561
6 · The paper itself

Abstract

A growing body of research supports the idea that the fallopian tube epithelium (FTE) is the precursor for most high-grade serous ovarian canacers (HGSOC) but that the ovary plays a critical role in tumor metastasis. Cortical inclusion cysts (CICs) in the ovarian cortex have been hypothesized to create a niche environment that plays a role in HGSOC progression. Through histological analysis of pathology samples from human ovaries, we determined that collagen I and III were elevated near CICs and that the collagen fibers in this dense region were oriented parallel to the cyst boundary. Using this information from human samples as design parameters, we engineered an

Indexed as

biomimetic modelcollagenECMhigh grade serous ovarian cancermicrofluidic deviceovary

Identifiers

PMID30556046
PMCPMC6294138
OpenAlexW2797408680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.