Evidence map›Paper›PMID 30556041›Full record

ArticleHepatology communications2018

Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na

Marion J D Robin, Monique D Appelman, Harmjan R Vos, Robert M van Es, James C Paton, Adrienne W Paton, Boudewijn Burgering, Peter Fickert, Jarom Heijmans, Stan F J van de Graaf

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. NTCP ubiquitination enables HBV infection.JHEP reports : innovation in hepatology · 2025
    Article
  3. Article
  4. The gut microbiota-bile acid axis in cholestatic liver disease.Molecular medicine (Cambridge, Mass.) · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Total flavonoids ofEvidence-based complementary and alternative medicine : eCAM · 2021
    Article
  11. Article
  12. Mechanistic insights into the inhibition of NTCP by myrcludex B.JHEP reports : innovation in hepatology · 2019
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Marion J D RobinAmsterdam UMC University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism Amsterdam the Netherlands.
Monique D AppelmanAmsterdam UMC University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism Amsterdam the Netherlands.
Harmjan R VosCenter for Molecular Medicine, Molecular Cancer Research Section University Medical Center Utrecht the Netherlands.
Robert M van EsCenter for Molecular Medicine, Molecular Cancer Research Section University Medical Center Utrecht the Netherlands.
James C PatonResearch Centre for Infectious Diseases, Department of Molecular and Cellular Biology University of Adelaide Adelaide Australia.
Adrienne W PatonResearch Centre for Infectious Diseases, Department of Molecular and Cellular Biology University of Adelaide Adelaide Australia.
Boudewijn BurgeringCenter for Molecular Medicine, Molecular Cancer Research Section University Medical Center Utrecht the Netherlands.
Peter FickertDivision of Gastroenterology and Hepatology, Department of Internal Medicine Medical University of Graz Graz Austria.
Jarom HeijmansAmsterdam UMC, University of Amsterdam Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism Amsterdam the Netherlands.
Stan F J van de GraafAmsterdam UMC University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism Amsterdam the Netherlands.ORCID 0000-0003-4238-4359
University Medical Center Utrecht · NLAmsterdam Neuroscience · NLAmsterdam University Medical Centers · NLCentre for Cancer Biology · AUMedical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholestasis-induced accumulation of bile acids in the liver leads to farnesoid X receptor (FXR)-mediated transcriptional down-regulation of the bile acid importer Na

Identifiers

PMID30556041
PMCPMC6287483
OpenAlexW2897674157

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.