Evidence map›Paper›PMID 30556036›Full record

ArticleHepatology communications2018

A Pathophysiologic Approach Combining Genetics and Insulin Resistance to Predict the Severity of Nonalcoholic Fatty Liver Disease.

Christopher J Danford, Margery A Connelly, Irina Shalaurova, Misung Kim, Mark A Herman, Imad Nasser, James D Otvos, Nezam H Afdhal, Z Gordon Jiang, Michelle Lai

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Impact of PNPLA3 I148M on Clinical Outcomes in Patients With MASLD.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Christopher J DanfordDivision of Gastroenterology and Hepatology Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA.
Margery A ConnellyLaboratory Corporation of America Holdings (LabCorp) Morrisville NC.
Irina ShalaurovaLaboratory Corporation of America Holdings (LabCorp) Morrisville NC.
Misung KimDivision of Endocrinology Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA.
Mark A HermanDivision of Endocrinology Duke University Medical Center Durham NC.
Imad NasserDepartment of Pathology Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA.
James D OtvosLaboratory Corporation of America Holdings (LabCorp) Morrisville NC.
Nezam H AfdhalDivision of Gastroenterology and Hepatology Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA.
Z Gordon JiangDivision of Gastroenterology and Hepatology Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA.
Michelle LaiDivision of Gastroenterology and Hepatology Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA.
Harvard University · USLabCorp (United States) · USBeth Israel Deaconess Medical Center · USDuke Medical Center · US

Funding

The Role of ChREBP in Fructose Induced Metabolic DiseaseR01DK100425 · NIDDK · DUKE UNIVERSITY · PI HERMAN, MARK A · 2014 to 2023
$3.6M
Non-invasive evaluation of Non-alcoholic SteatohepatitisK23DK083439 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LAI, MICHELLE · 2010 to 2014
$887k
NIDDK NIH HHS K23 DK083439NIDDK NIH HHS R01 DK100425
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a complex disease dictated by both genetic and environmental factors. While insulin resistance (IR) is a key pathogenic driver, two common genetic variants in patatin-like phospholipase domain containing 3 (

Identifiers

PMID30556036
PMCPMC6287585
OpenAlexW2898980141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.