ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2018
CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
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- A remote digital memory composite to detect cognitive impairment in memory clinic samples in unsupervised settings using mobile devices.NPJ digital medicine · 2024Article
- Reduced expression of fMRI subsequent memory effects with increasing severity across the Alzheimer's disease risk spectrum.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults.iScience · 2023Article
- The relationship between resting-state amplitude fluctuations and memory-related deactivations of the default mode network in young and older adults.Human brain mapping · 2023Article
- Single-value scores of memory-related brain activity reflect dissociable neuropsychological and anatomical signatures of neurocognitive aging.Human brain mapping · 2023Article
- Assessing mild cognitive impairment using object-location memory in immersive virtual environments.Hippocampus · 2022Article
- Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease.Neurology · 2022Article
- Amyloid pathology but not APOE ε4 status is permissive for tau-related hippocampal dysfunction.Brain : a journal of neurology · 2022Article
- Unsupervised mobile app-based cognitive testing in a population-based study of older adults born 1944.Frontiers in digital health · 2022Article
- Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults.Frontiers in psychology · 2022Article
- Feasibility of Digital Memory Assessments in an Unsupervised and Remote Study Setting.Frontiers in digital health · 2022Article
- A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging.Human brain mapping · 2021Article
- Studying Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis with 7-T magnetic resonance.European radiology experimental · 2021Review
- Reduced Repetition Suppression in Aging is Driven by Tau-Related Hyperactivity in Medial Temporal Lobe.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
Corrections and comments
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Authors and funding
40 authors at 12 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe examined the association between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, neural novelty responses, and brain volume in predementia old age.
methodsWe conducted a cross-sectional analysis of the observational, multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Seventy-six participants completed task functional magnetic resonance imaging and provided CSF (40 cognitively unimpaired, 21 experiencing subjective cognitive decline, and 15 with mild cognitive impairment). We assessed the correlation between CSF biomarkers and whole-brain functional magnetic resonance imaging novelty responses to scene images.
resultsTotal tau levels were specifically and negatively associated with novelty responses in the right amygdala and right hippocampus. Mediation analyses showed no evidence that these associations were dependent on the volume of hippocampus/amygdala. No relationship was found between phosphorylated-tau or Aβ DISCUSSION: Our data show that CSF levels of total tau are associated with anatomically specific reductions in novelty processing, which cannot be fully explained by atrophy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.