ArticleFrontiers in chemistry2018
The Assembling and Contraction Mechanisms of Striated Muscles.
Article in Frontiers in chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
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- Identification of a Gene Prognostic Model of Gastric Cancer Based on Analysis of Tumor Mutation Burden.Pathology oncology research : POR · 2021Article
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- Supramolecular and Liquid Crystalline Contributions to the Assembly of Myofibril.Molecules (Basel, Switzerland) · 2020Article
- Titin mutation associated with responsiveness to checkpoint blockades in solid tumors.JCI insight · 2019Article
- A Supramolecular Polymerization Approach to the Growth of the Myofibril.Frontiers in chemistry · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
A novel approach to the description of the assembly mechanism of functional biological structures is presented. The approach is based on the identification of fundamental self-assembling processes to which an additional structurization "engineered" by Nature to optimize functions is superimposed. Application of the approach to the structure and contraction of the striated muscle evidences a key role of the residual liquid crystallinity of a constrained structure and the alteration of the compatibility between the thin and thick filaments driven by ionic interactions. ATP hydrolysis boosts the relaxation process. A strong protein scaffold, engineered during the evolutionary process and based on the selective anchoring of coordinated filaments, directs a demixing tendency of the two filaments toward a sliding motion along the fiber axis. The Huxley-Hanson sliding filament hypothesis aimed to explain the contraction-relaxation function of the striated muscle, but does not offer any clue on the overall assembling mechanism of the myofibril.
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Registered trials
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