Evidence map›Paper›PMID 30555746›Full record

ArticleAmerican journal of cancer research2018

ANKHD1 silencing suppresses the proliferation, migration and invasion of CRC cells by inhibiting YAP1-induced activation of EMT.

Ping'an Yao, Yecheng Li, Wenqi Shen, Xiaohui Xu, Wei Zhu, Xiaodong Yang, Jianping Cao, Chungen Xing

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ping'an YaoDepartment of General Surgery, The Second Affiliated Hospital of Soochow University No.1055 Sanxiang Road, Suzhou 215004, China.
Yecheng LiDepartment of General Surgery, The Second Affiliated Hospital of Soochow University No.1055 Sanxiang Road, Suzhou 215004, China.
Wenqi ShenDepartment of General Surgery, The Second Affiliated Hospital of Soochow University No.1055 Sanxiang Road, Suzhou 215004, China.
Xiaohui XuDepartment of General Surgery, The Second Affiliated Hospital of Soochow University No.1055 Sanxiang Road, Suzhou 215004, China.
Wei ZhuSchool of Radiation Medicine and Protection, Medical College of Soochow University Suzhou 215123, China.
Xiaodong YangDepartment of General Surgery, The Second Affiliated Hospital of Soochow University No.1055 Sanxiang Road, Suzhou 215004, China.
Jianping CaoSchool of Radiation Medicine and Protection, Medical College of Soochow University Suzhou 215123, China.
Chungen XingDepartment of General Surgery, The Second Affiliated Hospital of Soochow University No.1055 Sanxiang Road, Suzhou 215004, China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ankyrin repeat and KH domain containing 1 (ANKHD1) is a protein with multiple ankyrin repeat domains and a single KH domain, and it is encoded by the ANKHD1 gene in humans. ANKHD1 has been reported to be highly expressed in various cancer tissues, and it is involved in cancer progression, including proliferation and invasion. However, its functional roles in colorectal cancer (CRC) remain unclear. In our study, we first found that high expression of ANKHD1 in CRC tumor tissue was associated with tumor infiltration depth (P=0.03). ANKHD1 was highly expressed in HCT116 and SW480 cells. Downregulation of ANKHD1 inhibited CRC cell proliferation, migration and invasion both

Indexed as

ANKHD1CRCEMTinvasionmigrationproliferationYAP1

Identifiers

PMID30555746
PMCPMC6291657
OpenAlexW2986461104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.