ArticleJournal of materials chemistry. B2018
Barcoding chemical modifications into nucleic acids improves drug stability
Article in Journal of materials chemistry. B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Single-cell RNA sequencing profiles drug activity within spatially engineered 3D cultures.Nature communications · 2026Article
- Review
- Designing Nanoparticle Surfaces with DNA Barcodes for Accurate In Vivo Quantification.JACS Au · 2025Article
- Recent strategies for enhanced delivery of mRNA to the lungs.Nanomedicine (London, England) · 2025Review
- Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery.Journal of controlled release : official journal of the Controlled Release Society · 2023Article
- Nanomedicine approaches for treatment of hematologic and oncologic malignancies.World journal of clinical oncology · 2022Review
- Correction of Beta-Thalassemia IVS-II-654 Mutation in a Mouse Model Using Prime Editing.International journal of molecular sciences · 2022Article
- Performance of nanoparticles for biomedical applications: TheBiophysics reviews · 2022Review
- DNA aptamers inhibit SARS-CoV-2 spike-protein binding to hACE2 by an RBD- independent or dependent approach.Theranostics · 2022Article
- Therapeutic RNA Delivery for COVID and Other Diseases.Advanced healthcare materials · 2021Review
- COVID-19: A challenge for electrochemical biosensors.Trends in analytical chemistry : TRAC · 2021Review
- Cell Subtypes Within the Liver Microenvironment Differentially Interact with Lipid Nanoparticles.Cellular and molecular bioengineering · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The efficacy of nucleic acid therapies can be limited by unwanted degradation. Chemical modifications are known to improve nucleic acid stability, but the (i) types, (ii) positions, and (iii) numbers of modifications all matter, making chemically optimizing nucleic acids a combinatorial problem. As a result,
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.