Evidence map›Paper›PMID 30555467›Full record

ReviewFrontiers in immunology2018

The Yin and Yang of Myeloid Derived Suppressor Cells.

Snehil Budhwar, Priyanka Verma, Rachna Verma, Sangeeta Rai, Kiran Singh

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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  5. Immune mediated support of metastasis: Implication for bone invasion.Cancer communications (London, England) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Snehil BudhwarDepartment of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, India.
Priyanka VermaDepartment of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, India.
Rachna VermaDepartment of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, India.
Sangeeta RaiDepartment of Obstetrics and Gynecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Kiran SinghDepartment of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, most of our knowledge about myeloid derived suppressor cells (MDSCs) has come from cancer studies, which depicts Yin side of MDSCs. In cancer, inherent immunosuppressive action of MDSCs favors tumor progression by inhibiting antitumor immune response. However, recently Yang side of MDSCs has also been worked out and suggests the role in maintenance of homeostasis during non-cancer situations like pregnancy, obesity, diabetes, and autoimmune disorders. Continued work in this area has armored the biological importance of these cells as master regulators of immune system and prompted scientists all over the world to look from a different perspective. Therefore, explicating Yin and Yang arms of MDSCs is obligatory to use it as a double edged sword in a much smarter way. This review is an attempt toward presenting a synergistic coalition of all the facts and controversies that exist in understanding MDSCs, bring them on the same platform and approach their "Yin and Yang" nature in a more comprehensive and coherent manner.

Indexed as

AnimalsAutoimmune DiseasesDiabetes MellitusFemaleHumansMaleMyeloid-Derived Suppressor CellsNeoplasmsObesityPregnancyepigeneticshomeostasisimmune regulationimmunosuppressionmyeloid derived suppressor cells

Identifiers

PMID30555467
PMCPMC6280921

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.