Evidence map›Paper›PMID 30555287›Full record

ArticleMicrofluidics and nanofluidics2018

Normally closed plunger-membrane microvalve self-actuated electrically using a shape memory alloy wire.

Chaojun Cheng, Ankitha Rajagopalan Nair, Raviraj Thakur, Gene Fridman

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Microfluidics and nanofluidics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. A microfluidic system integrated with shape memory alloy valves for a safe direct current delivery system.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2020
    Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chaojun ChengMechanical Engineering, Johns Hopkins University, Baltimore, USA.
Ankitha Rajagopalan NairBiomedical Engineering, Johns Hopkins University, Baltimore, USA.
Raviraj ThakurOtolaryngology HNS, Johns Hopkins University, Baltimore, USA.
Gene FridmanOtolaryngology HNS, Johns Hopkins University, Baltimore, USA.

Funding

Safe Direct Current for Neuroprosthetic ApplicationsR01NS092726 · NINDS · JOHNS HOPKINS UNIVERSITY · PI FRIDMAN, GENE YEVGENY · 2015 to 2019
$1.7M
NINDS NIH HHS R01 NS092726
6 · The paper itself

Abstract

Various microfluidic architectures designed for in vivo and point-of-care diagnostic applications require larger channels, autonomous actuation, and portability. In this paper, we present a normally closed microvalve design capable of fully autonomous actuation for wide diameter microchannels (tens to hundreds of μm). We fabricated the multilayer plunger-membrane valve architecture using the silicone elastomer, poly-dimethylsiloxane (PDMS) and optimized it to reduce the force required to open the valve. A 50-μm Nitinol (NiTi) shape memory alloy wire is incorporated into the device and can operate the valve when actuated with 100-mA current delivered from a 3-V supply. We characterized the valve for its actuation kinetics using an electrochemical assay and tested its reliability at 1.5-s cycle duration for 1 million cycles during which we observed no operational degradation.

Indexed as

NitinolPDMSPoint-of-careSelf-actuatedValve

Identifiers

PMID30555287
PMCPMC6291303

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.