Evidence map›Paper›PMID 30555217›Full record

ArticleChild & youth care forum2018

Pharmacotherapy Adherence for Pediatric Anxiety Disorders: Predictors and Relation to Child Outcomes.

Asima Zehgeer, Golda S Ginsburg, Phyllis Lee, Boris Birmaher, John Walkup, Philip C Kendall, Dara Sakolsky, Tara Peris

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Child & youth care forum, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Asima ZehgeerUniversity of Connecticut School of Medicine Department of Psychiatry, Farmington, CT.
Golda S GinsburgUniversity of Connecticut School of Medicine Department of Psychiatry, Farmington, CT.
Phyllis LeeUniversity of Connecticut School of Medicine Department of Psychiatry, Farmington, CT.
Boris BirmaherUniversity of Pittsburgh Medical Center Department of Psychiatry, Pittsburgh, PA.
John WalkupWeill Cornell Medical College Department of Psychiatry New York, NY.
Philip C KendallTemple University Department of Psychology, Philadelphia, PA.
Dara SakolskyUniversity of Pittsburgh Medical Center Department of Psychiatry, Pittsburgh, PA.
Tara PerisUniversity of California, Los Angeles Department of Psychiatry, Los Angeles, CA.
University of Connecticut · USUniversity of Pittsburgh Medical Center · USLurie Children's Hospital · USTemple University · USUniversity of California, Los Angeles · US

Funding

Child/Adolescent Anxiety Multimodal Treatment StudyU01MH064089 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GINSBURG, GOLDA SUSAN · 2002 to 2007
$3.1M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH064003 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS · 2002 to 2007
$2.7M
Child/Adolescent Anxiety Multimodal Treatment Study (CAMS)U01MH064092 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ALBANO, ANNE MARIE · 2002 to 2007
$2.4M
Child and Adolescent Anxiety Multisite Study (CAMS)U01MH064107 · NIMH · DUKE UNIVERSITY · PI MARCH, JOHN S · 2002 to 2007
$2.4M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH063747 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI KENDALL, PHILIP C · 2002 to 2007
$2.2M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH064088 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIACENTINI, JOHN C. · 2002 to 2007
$2.1M
Integrating Biological Markers into Clinical ResearchK24MH096760 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GINSBURG, GOLDA SUSAN · 2013 to 2016
$653k
NIMH NIH HHS K24 MH096760NIMH NIH HHS U01 MH063747NIMH NIH HHS U01 MH064003NIMH NIH HHS U01 MH064088NIMH NIH HHS U01 MH064089NIMH NIH HHS U01 MH064092NIMH NIH HHS U01 MH064107
6 · The paper itself

Abstract

backgroundPharmacotherapy is considered an evidenced-based treatment for anxious youth. There is a need to better understand the relation between medication adherence and child outcomes.

objectiveThis study prospectively examined:1) baseline predictors of adherence and 2) the relation between medication adherence and clinical outcomes in children and adolescents with anxiety disorders.

methodsParticipants were 349 youth randomized to sertraline, pill placebo, or sertraline plus cognitive behavioral therapy in the Child/Adolescent Anxiety Multimodal Study (CAMS) and followed over 12 weeks. The measure of pharmacotherapy adherence used was pharmacotherapist (PT) ratings of adherence at each session. Four domains of baseline predictors were examined (demographics, child clinical variables, family/parent variables, and treatment variables).

resultsMultiple regression analyses revealed few significant predictors of adherence. The most robust predictors of greater adherence were living with two parents and parents' positive expectations that medication would lead to better outcomes. Pharmacotherapists' ratings of higher adherence predicted higher global functioning at post treatment and treatment responder status.

conclusionsIn order to increase adherence, improving expectations and instilling hope for positive outcomes and problem solving ways to overcome pragmatic barriers associated with single parent families is recommended.

Indexed as

adherenceanxietyselective serotonin reuptake inhibitors

Identifiers

PMID30555217
PMCPMC6289191
OpenAlexW2808383955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.