ArticleComputers & chemical engineering2018
Modeling Sex Differences in the Renin Angiotensin System and the Efficacy of Antihypertensive Therapies.
Article in Computers & chemical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Mathematical modeling of impacts of patient differences on renin-angiotensin system and applications to COVID-19 lung fibrosis outcomes.Computers in biology and medicine · 2025Article
- Article
- Predicting sex differences in the effects of diuretics in renal epithelial transport during angiotensin II-induced hypertension.American journal of physiology. Renal physiology · 2024Article
- Sex differences in renal transporters: assessment and functional consequences.Nature reviews. Nephrology · 2024Review
- Understanding the Mechanisms and Treatment of Heart Failure: Quantitative Systems Pharmacology Models with a Focus on SGLT2 Inhibitors and Sex-Specific Differences.Pharmaceutics · 2023Review
- Sex differences in circadian regulation of kidney function of the mouse.American journal of physiology. Renal physiology · 2022Article
- A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls.PLoS computational biology · 2022Article
- Isoflavone daidzein ameliorates renal dysfunction and fibrosis in a postmenopausal rat model: Intermediation of angiotensin AT1 and Mas receptors and microRNAs 33a and 27a.Iranian journal of basic medical sciences · 2022Article
- Article
- A Computational Model of Kidney Function in a Patient with Diabetes.International journal of molecular sciences · 2021Review
- Sex differences in soluble prorenin receptor in patients with type 2 diabetes.Biology of sex differences · 2021Article
- Impact of sex and pathophysiology on optimal drug choice in hypertensive rats: quantitative insights for precision medicine.iScience · 2021Article
- Systemic Candesartan Treatment Modulates Behavior, Synaptic Protein Levels, and Neuroinflammation in Female Mice That Express HumanFrontiers in neuroscience · 2021Article
- Modeling the Molecular Impact of SARS-CoV-2 Infection on the Renin-Angiotensin System.Viruses · 2020Article
- Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers During the COVID-19 Pandemic: A Modeling Analysis.PLoS computational biology · 2020Article
- Prevalence of Angiotensin II Type 1 Receptor Antibodies in Persons With Hypertension and Relation to Blood Pressure and Medication.American journal of hypertension · 2020Article
- Sex-specific computational models for blood pressure regulation in the rat.American journal of physiology. Renal physiology · 2020Article
- Understanding sex differences in long-term blood pressure regulation: insights from experimental studies and computational modeling.American journal of physiology. Heart and circulatory physiology · 2019Article
- Sex-specific long-term blood pressure regulation: Modeling and analysis.Computers in biology and medicine · 2019Article
- Sex Differences in Hypertension: Where We Have Been and Where We Are Going.American journal of hypertension · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The renin angiotensin system is a major regulator of blood pressure and a target for many anti-hypertensive therapies; yet the efficacy of these treatments varies between the sexes. We use published data for systemic RAS hormones to build separate models for four groups of rats: male normotensive, male hypertensive, female normotensive, and female hypertensive rats. We found that plasma renin activity, angiotensinogen production rate, angiotensin converting enzyme activity, and neutral endopeptidase activity differ significantly among the four groups of rats. Model results indicate that angiotensin converting enzyme inhibitors and angiotensin receptor blockers induce similar
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.