ArticleJournal of epidemiology2019
Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study.
Article in Journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The relationship between body mass index and stroke: a systemic review and meta-analysis.Journal of neurology · 2022Pooled it
- Elucidating the causal role of age of menarche, adiposity, lipid fractions, and blood pressure upon cardiovascular disease: a multivariable Mendelian randomization study.Journal of human hypertension · 2025Article
- Alteration of brain metabolism in lacunar stroke based onFrontiers in neurology · 2025Article
- Atherogenic index of plasma and obesity-related risk of stroke in middle-aged and older Chinese adults: a national prospective cohort study.Diabetology & metabolic syndrome · 2024Article
- Nonrestorative Sleep and Type 2 Diabetes Incidence: The Aichi Workers' Cohort Study.Journal of epidemiology · 2024Article
- Body Mass Index Asian populations category and stroke and heart disease in the adult population: a longitudinal study of the Indonesia Family Life Survey (IFLS) 2007 and 2014.BMC public health · 2023Article
- Body Mass Index and Late Adverse Outcomes after a Carotid Endarterectomy.International journal of environmental research and public health · 2023Article
- Women's reproductive traits and ischemic stroke: a two-sample Mendelian randomization study.Annals of clinical and translational neurology · 2023Article
- Influence of BMI on adenosine deaminase and stroke outcomes in mechanical thrombectomy subjects.Brain, behavior, & immunity - health · 2022Article
- Combined consideration of body mass index and waist circumference identifies obesity patterns associated with risk of stroke in a Chinese prospective cohort study.BMC public health · 2022Article
- Body mass index has a non-linear association with three-month outcomes in men with acute ischemic stroke: An analysis based on data from a prospective cohort study.Frontiers in endocrinology · 2022Article
- The Lifelong Health Support 10: a Japanese prescription for a long and healthy life.Environmental health and preventive medicine · 2022Review
- Article
- Estimation of 10-Year Risk of Death from Coronary Heart Disease, Stroke, and Cardiovascular Disease in a Pooled Analysis of Japanese Cohorts: EPOCH-JAPAN.Journal of atherosclerosis and thrombosis · 2021Article
- Modifiable Risk Factors for Cardiovascular Disease in Korea and Japan.Korean circulation journal · 2021Review
- The association between serine hydroxymethyl transferase 1 gene hypermethylation and ischemic stroke.Bosnian journal of basic medical sciences · 2021Article
- Machine Learning-Based Model for Predicting Incidence and Severity of Acute Ischemic Stroke in Anterior Circulation Large Vessel Occlusion.Frontiers in neurology · 2021Article
- Associations between cerebral magnetic resonance imaging infarct volume and acute ischemic stroke etiology.PloS one · 2021Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association of body mass index (BMI) with risks of ischemic stroke subtypes have not been established.
methodsCumulative average BMI was calculated using self-reported body weight and height obtained from baseline (Cohort I in 1990, and Cohort II from 1993-1994) and 5- and 10-year questionnaire surveys of Japan Public Health Center-based prospective (JPHC) study. A total of 42,343 men and 46,413 women aged 40-69 years were followed-up for the incidence of lacunar, large-artery occlusive, and cardioembolic strokes. A sub-distribution hazard model was used to estimate sub-distribution hazard ratios (SHRs) and the 95% confidence intervals (CIs).
resultsDuring a median of 20.0 years of follow-up, we documented 809 and 481 lacunar, 395 and 218 large-artery occlusive, and 568 and 298 cardioembolic strokes in men and women, respectively. After adjustment for baseline age, updated smoking, alcohol consumption, leisure-time physical activity, and histories of hypertension, dyslipidemia, and diabetes mellitus, cumulative average BMI was positively linearly associated with lacunar (trend P = 0.007), large-artery occlusive (trend P = 0.002), and cardioembolic (trend P < 0.001) strokes in men, and with lacunar (trend P < 0.001) and large-artery occlusive (trend P = 0.003) strokes in women. There were approximately two-fold excess risk of cardioembolic stroke in both sexes and of lacunar and large-artery occlusive strokes in women for cumulative average BMI ≥30 kg/m
conclusionCumulative average BMI showed a positive linear effect on sub-distribution hazards of lacunar, large-artery occlusive, and cardioembolic strokes in both sexes, except for cardioembolic stroke in women.
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