Evidence map›Paper›PMID 30554997›Full record

SynthesisThe Lancet. Infectious diseases2019

Spatially targeted screening to reduce tuberculosis transmission in high-incidence settings.

Patrick G T Cudahy, Jason R Andrews, Alyssa Bilinski, David W Dowdy, Barun Mathema, Nicolas A Menzies, Joshua A Salomon, Sourya Shrestha, Ted Cohen

Abstract readSystematic Review
In one paragraph

Synthesis in The Lancet. Infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Genomic epidemiology ofMicrobial genomics · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Spatio-temporal patterns of tuberculosis revealed by routineThe Lancet regional health. Western Pacific · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Mobility patterns, activity locations, and TB in Nairobi, Kenya.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Patrick G T CudahySection of Infectious Disease, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA. Electronic address: patrick.cudahy@yale.edu.
Jason R AndrewsDivision of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Alyssa BilinskiInterfaculty Initiative in Health Policy, Harvard Graduate School of Arts and Sciences, Cambridge, MA, USA.
David W DowdyDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Barun MathemaDepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.
Nicolas A MenziesDepartment of Global Health and Population, Harvard T H Chan School of Public Health, Boston, MA, USA.
Joshua A SalomonDepartment of Global Health and Population, Harvard T H Chan School of Public Health, Boston, MA, USA; Center for Health Policy and Center for Primary Care and Outcomes Research, Stanford University, Stanford, CA, USA.
Sourya ShresthaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Ted CohenDepartment of Epidemiology (Microbial Diseases), Yale University School of Public Health, New Haven, CT, USA.
Harvard Global Health Institute · USJohns Hopkins University · USYale University · USColumbia University · USStanford University · US

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
TRAINING IN THE PATHOGENESIS OF INFECTIOUS DISEASEST32AI007517 · NIAID · YALE UNIVERSITY · PI Jaimie Meyer, Albert C Shaw · 1997 to 2026
$6.1M
Global Health Fellows and Scholars Research TrainingR25TW009338 · FIC · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARRY, MICHELE, KO, ALBERT ICKSANG · 2012 to 2016
$5.2M
Evaluating health and economic effects of targeted strategies in TB/HIVR01AI112438 · NIAID · YALE UNIVERSITY · PI COHEN, THEODORE H, SALOMON, JOSHUA A · 2014 to 2017
$2.4M
FIC NIH HHS D43 TW010540FIC NIH HHS R25 TW009338Intramural NIH HHS Z99 AI999999NIAID NIH HHS HHSN272201600001CNIAID NIH HHS HHSN272201600001GNIAID NIH HHS R01 AI112438NIAID NIH HHS T32 AI007433NIAID NIH HHS T32 AI007517
6 · The paper itself

Abstract

As the leading infectious cause of death worldwide and the primary proximal cause of death in individuals living with HIV, tuberculosis remains a global concern. Existing tuberculosis control strategies that rely on passive case-finding appear insufficient to achieve targets for reductions in tuberculosis incidence and mortality. Active case-finding strategies aim to detect infectious individuals earlier in their infectious period to reduce onward transmission and improve treatment outcomes. Empirical studies of active case-finding have produced mixed results and determining how to direct active screening to those most at risk remains a topic of intense research. Our systematic review of literature evaluating the effects of geographically targeted tuberculosis screening interventions found three studies in low tuberculosis incidence settings, but none conducted in high tuberculosis incidence countries. We discuss open questions related to the use of spatially targeted approaches for active screening in countries where tuberculosis incidence is highest.

Indexed as

AdultAIDS-Related Opportunistic InfectionsCommunicable Disease ControlHIVHumansIncidenceMass ScreeningMycobacterium tuberculosisPrevalenceTuberculosis, Multidrug-ResistantWhole Genome Sequencing

Identifiers

PMID30554997
PMCPMC6401264
OpenAlexW2905129234

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.