Evidence map›Paper›PMID 30554963›Full record

ReviewCell stem cell2019

Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance.

Piyush B Gupta, Ievgenia Pastushenko, Adam Skibinski, Cedric Blanpain, Charlotte Kuperwasser

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell stem cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 381 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
381citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

381 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Cell plasticity in cancer and therapy resistance.Experimental & molecular medicine · 2026
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  18. Cancer Evolvability Determines Therapy Outcomes.bioRxiv : the preprint server for biology · 2026
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321 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Piyush B GuptaWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: piyush@mit.edu.
Ievgenia PastushenkoUniversité Libre de Bruxelles, Laboratory of Stem Cells and Cancer, Brussels 1070, Belgium.
Adam SkibinskiDepartment of Developmental, Chemical and Molecular Biology, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, USA; Raymond and Beverly Sackler Convergence Laboratory, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, USA; Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington St., Boston, MA 02111, USA.
Cedric BlanpainUniversité Libre de Bruxelles, Laboratory of Stem Cells and Cancer, Brussels 1070, Belgium; WELBIO, Université Libre de Bruxelles, Brussels 1070, Belgium. Electronic address: cedric.blanpain@ulb.ac.be.
Charlotte KuperwasserUniversité Libre de Bruxelles, Laboratory of Stem Cells and Cancer, Brussels 1070, Belgium; Department of Developmental, Chemical and Molecular Biology, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, USA; Raymond and Beverly Sackler Convergence Laboratory, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, USA. Electronic address: charlotte.kuperwasser@tufts.edu.

Funding

Analysis of the cellular and molecular determinants of the human breast hierarchyR01HD073035 · NICHD · TUFTS UNIVERSITY BOSTON · PI KUPERWASSER, CHARLOTTE · 2012 to 2016
$2.4M
Defining the signaling pathways that direct adult tissue stem cells to exit multipotencyR01GM124491 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI GUPTA, PIYUSH · 2018 to 2022
$2.1M
NICHD NIH HHS R01 HD073035NIGMS NIH HHS R01 GM124491
6 · The paper itself

Abstract

Our traditional understanding of phenotypic plasticity in adult somatic cells comprises dedifferentiation and transdifferentiation in the context of tissue regeneration or wound healing. Although dedifferentiation is central to tissue repair and stemness, this process inherently carries the risk of cancer initiation. Consequently, recent research suggests phenotypic plasticity as a new paradigm for understanding cancer initiation, progression, and resistance to therapy. Here, we discuss how cells acquire plasticity and the role of plasticity in initiating cancer, cancer progression, and metastasis and in developing therapy resistance. We also highlight the epithelial-to-mesenchymal transition (EMT) and known molecular mechanisms underlying plasticity and we consider potential therapeutic avenues.

Indexed as

Adaptation, PhysiologicalDrug Resistance, NeoplasmEpithelial-Mesenchymal TransitionAnimalsDisease ProgressionHumansNeoplasmsNeoplastic Stem Cellscancerepithelial to mesenchymal transitionplasticitytherapy resistance

Identifiers

PMID30554963
PMCPMC7297507

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.