ArticleCurrent biology : CB2019
Predominant Striatal Input to the Lateral Habenula in Macaques Comes from Striosomes.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Prediction error correlates in the striosome-dopamine circuit emerge from information gain.Nature communications · 2026Article
- Striosomal ghrelin receptor activity controls reward-cost integration.Research square · 2026Article
- Whole-Brain Mapping of Neuronal Activity Associated with Vocal Socialization Behaviors in Adult Mice.eNeuro · 2026Article
- Dorsomedial striatum monitors unreliability of current action policy and probes alternative one via the indirect pathway.Science advances · 2025Article
- The role of dorsomedial striatum and parvalbumin interneurons in schizophrenia-related cognitive deficits: insights from disrupted strategic decision-making in Akt1 heterozygous mice.Translational psychiatry · 2025Article
- Patchy striatonigral neurons modulate locomotor vigor in response to environmental valence.eLife · 2025Article
- A decision-space model explains context-specific decision-making.Nature communications · 2025Article
- Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence.bioRxiv : the preprint server for biology · 2025Article
- Striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits.Current biology : CB · 2024Article
- A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens.Scientific reports · 2024Article
- Striosomes Target Nigral Dopamine-Containing Neurons via Direct-D1 and Indirect-D2 Pathways Paralleling Classic Direct-Indirect Basal Ganglia Systems.bioRxiv : the preprint server for biology · 2024Article
- Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder.Nature communications · 2024Article
- Putative role of immune reactions in the mechanism of tardive dyskinesia.Brain, behavior, & immunity - health · 2023Review
- Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder.Frontiers in neurology · 2023Article
- Article
- Distinct Roles of the Human Subthalamic Nucleus and Dorsal Pallidum in Parkinson's Disease Impulsivity.Biological psychiatry · 2022Article
- Transcriptional and anatomical diversity of medium spiny neurons in the primate striatum.Current biology : CB · 2021Article
- Discovering the Lost Reward: Critical Locations for Endocannabinoid Modulation of the Cortico-Striatal Loop That Are Implicated in Major Depression.International journal of molecular sciences · 2021Review
- Causal Evidence for Induction of Pessimistic Decision-Making in Primates by the Network of Frontal Cortex and Striosomes.Frontiers in neuroscience · 2021Article
- Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model.Cell · 2020Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Striosomes, neurochemically specialized modules in the striatum, are thought to be nodes in circuits extending, via basal ganglia pathways, from mood-related neocortical regions to dopamine-containing neurons of the substantia nigra. Yet striosomes have remained beyond the reach of electrophysiological methods to identify them, especially in non-human primates. Such work is needed for translational as well as for basic science. Here we introduce a method to identify striosomes on-line in awake, behaving macaques. We combined electrical microstimulation of the striatum with simultaneous electrophysiological recording in the lateral habenula (LHb) followed by immunohistochemistry. We demonstrate that striosomes provide the predominant striatal input to the macaque pallido-habenular circuit, which is known to function in relation to reinforcement signaling. Further, our experiments suggest that striosomes from different striatal regions may convergently influence the lateral habenula. This work now opens the way to defining the functions of striosomes in behaving primates in relation to mood, motivation, and action.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.