Evidence map›Paper›PMID 30554789›Full record

Trial reportThe Journal of pediatrics2019

Effects of Exercise Modality on Insulin Resistance and Ectopic Fat in Adolescents with Overweight and Obesity: A Randomized Clinical Trial.

SoJung Lee, Ingrid Libman, Kara Hughan, Jennifer L Kuk, Jong H Jeong, Di Zhang, Silva Arslanian

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01938950 (Resistance and Cardiorespiratory Time-matched Exercise in Youth), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01938950 naterminatednot on this map

Resistance and Cardiorespiratory Time-matched Exercise in Youth: A Randomized Clinical Trial (RCT:RCT)

TypeinterventionalSponsorUniversity of PittsburghRan2013 to 2017Enrolled118ConditionsChildhood ObesityArmsAerobic Exercise, Resistance Exercise, Aerobic and Resistance Exercise
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

SoJung LeeDivision of Sports Medicine, Graduate School of Physical Education, Kyung Hee University, Yongin, Republic of Korea. Electronic address: sojung.lee@khu.ac.kr.
Ingrid LibmanDivision of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
Kara HughanDivision of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
Jennifer L KukSchool of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.
Jong H JeongDepartment of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Di ZhangDepartment of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Silva ArslanianDivision of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC, School of Medicine, University of Pittsburgh, Pittsburgh, PA; Center for Pediatric Research in Obesity and Metabolism Children's Hospital of Pittsburgh of UPMC, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
University of Pittsburgh · USKyung Hee University · KRYork University · CA

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Resistance and Cardiorespiratory Time-matched Exercise Training in Youth: A RandoR01HL114857 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, SOJUNG · 2013 to 2016
$4.3M
RESEARCH TRAINING IN PEDIATRIC ENDOCRINOLOGY &DIABETEST32DK007729 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MUZUMDAR, RADHIKA HIREN · 1995 to 2020
$3.3M
Nitrite Modulation of Hypertension, Platelet Activation and Endothelial and Mitochondrial FunctionK23HL124051 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUGHAN, KARA S. · 2015 to 2017
$471k
NCATS NIH HHS UL1 TR000005NCRR NIH HHS UL1 RR024153NHLBI NIH HHS K23 HL124051NHLBI NIH HHS R01 HL114857NIDDK NIH HHS T32 DK007729
6 · The paper itself

Abstract

objectiveTo examine whether a combined aerobic exercise and resistance exercise is more effective than either aerobic exercise or resistance exercise alone in improving insulin sensitivity and reducing total adiposity and ectopic fat in adolescents. STUDY

designA total of 118 sedentary adolescents with overweight/obesity (body mass index >85th percentile, 12-17 years) were recruited from October 2013 through April 2017 at Children's Hospital of Pittsburgh. Participants were randomized to 1 of the following 6-month exercise groups (3 d/wk, 180 min/wk): aerobic exercise (n = 38), resistance exercise (n = 40), and combined aerobic exercise and resistance exercise (n = 40). The primary outcome was the change in insulin-stimulated glucose disposal by a 3-hour hyperinsulinemic-euglycemic clamp. The secondary outcomes were changes in liver fat by proton magnetic resonance spectroscopy and intermuscular adipose tissue by computed tomography.

resultsOf the 118 participants randomized, 85 participants (72%) completed the study with 90% exercise attendance. Total adiposity reduced similarly in all groups (-2%, P < .05). After adjusting for age and sex, insulin-stimulated glucose disposal increased (P < .05) in all groups, with the increase in the aerobic exercise group being greater than the resistance exercise group (1.7 ± 0.1 vs 0.7 ± 0.1 mg/kg/min, P < .05) but not different from the combined group (1.2 ± 0.1 mg/kg/min). Liver fat was reduced (P < .05) in the aerobic exercise (-0.6%) and combined (-0.6%) groups but not in the resistance exercise group (-0.3%, P > .05). Intermuscular adipose tissue decreased (P < .05) similarly in all groups.

conclusionCombined aerobic exercise and resistance exercise and aerobic exercise alone are similarly beneficial in improving insulin sensitivity and reducing ectopic fat in adolescents with obesity.

trial registrationClinicalTrials.gov: NCT01938950.

Indexed as

ExerciseInsulin ResistanceAdipose TissueAdiposityAdolescentAnthropometryBody Mass IndexChildDietExercise TherapyFatty LiverFemaleGlucose Tolerance TestHumansInsulinMaleInsulinchildhood obesityexerciseinsulin sensitivityintermuscular fatliver fat

Identifiers

PMID30554789
PMCPMC7193538
OpenAlexW2903691667

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.