Evidence map›Paper›PMID 30554720›Full record

ArticleAmerican journal of human genetics2019

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.

Nasim Mavaddat, Kyriaki Michailidou, Joe Dennis, Michael Lush, Laura Fachal, Andrew Lee, Jonathan P Tyrer, Ting-Huei Chen, Qin Wang, Manjeet K Bolla and 262 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05570266 (Genetic and Non-Genetic Breast Cancer Risk Prediction Evaluation in Indonesian Samples), which is not on this map. Cited by 647 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
647citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05570266 completednot on this mapstarted 2020, after this paper: background citation

Genetic and Non-Genetic Breast Cancer Risk Prediction Evaluation in Indonesian Samples

Typeobservational_patient_registrySponsorNalagenetics Pte LtdRan2020 to 2023Enrolled322ConditionsBreast CancerArmsBreast Cancer Risk Prediction Software
3 · Its place in the literature

Who cites it

647 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
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  14. Review
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  16. PRS-BCJournal of medical genetics · 2026
    Article
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587 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

272 authors.

Nasim MavaddatCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK. Electronic address: nm274@medschl.cam.ac.uk.
Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, 1683 Nicosia, Cyprus.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Michael LushCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Laura FachalCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Andrew LeeCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Jonathan P TyrerCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Ting-Huei ChenDepartment of Mathematics and Statistics, Laval University, Québec City, QC G1V 0A6, Canada.
Qin WangCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Xin YangCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Muriel A AdankFamily Cancer Clinic, the Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, 1066 CX, the Netherlands.
Thomas AhearnDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20850, USA.
Kristiina AittomäkiDepartment of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki 00290, Finland.
Jamie AllenCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Irene L AndrulisFred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Hoda Anton-CulverDepartment of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA 92617, USA.
Natalia N AntonenkovaNN Alexandrov Research Institute of Oncology and Medical Radiology, Minsk 223040, Belarus.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Kristan J AronsonDepartment of Public Health Sciences, and Cancer Research Institute, Queen's University, Kingston, ON K7L 3N6, Canada.
Paul L AuerCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI 53205, USA.
Päivi AuvinenCancer Center, Kuopio University Hospital, Kuopio 70210, Finland; Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio 70210, Finland; Translational Cancer Research Area, University of Eastern Finland, Kuopio 70210, Finland.
Myrto BarrdahlDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Laura E Beane FreemanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20850, USA.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen 91054, Germany.
Sabine BehrensDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Javier BenitezHuman Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain; Biomedical Network on Rare Diseases (CIBERER), Madrid 28029, Spain.
Marina BermishevaInstitute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa 450054, Russia.
Leslie BernsteinDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Carl BlomqvistDepartment of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki 00290, Finland; Department of Oncology, Örebro University Hospital, Örebro 70185, Sweden.
Natalia V BogdanovaNN Alexandrov Research Institute of Oncology and Medical Radiology, Minsk 223040, Belarus; Department of Radiation Oncology, Hannover Medical School, Hannover 30625, Germany; Gynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany.
Stig E BojesenCopenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev 2730, Denmark; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev 2730, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Bernardo BonanniDivision of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan 20141, Italy.
Anne-Lise Børresen-DaleDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo 0379, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo 0450, Norway.
Hiltrud BrauchDr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart 70376, Germany; University of Tübingen, Tübingen 72074, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Michael BremerDepartment of Radiation Oncology, Hannover Medical School, Hannover 30625, Germany.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg 69120, Germany.
Adam BrentnallCentre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London EC1M 6BQ, UK.
Ian W BrockSheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2TN, UK.
Angela Brooks-WilsonGenome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Sara Y BruckerDepartment of Gynecology and Obstetrics, University of Tübingen, Tübingen 72076, Germany.
Thomas BrüningInstitute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum 44789, Germany.
Barbara BurwinkelDepartment of Obstetrics and Gynecology, University of Heidelberg, Heidelberg 69120, Germany; Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Daniele CampaDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; Department of Biology, University of Pisa, Pisa 56126, Italy.
Brian D CarterEpidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA.
Jose E CastelaoOncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo 36312, Spain.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20850, USA.
Rowan ChlebowskiDivision of Medical Oncology and Hematology, University of California at Los Angeles, Los Angeles, CA 90024, USA.
Hans ChristiansenDepartment of Radiation Oncology, Hannover Medical School, Hannover 30625, Germany.
Christine L ClarkeWestmead Institute for Medical Research, University of Sydney, Sydney, NSW 2145, Australia.
J Margriet ColléeDepartment of Clinical Genetics, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Emilie Cordina-DuvergerCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif 94805, France.
Sten CornelissenDivision of Molecular Pathology, the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam 1066 CX, the Netherlands.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Angela CoxSheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2TN, UK.
Simon S CrossAcademic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2TN, UK.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 65, Sweden.
Mary B DalyDepartment of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Peter DevileeDepartment of Pathology, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany.
Isabel Dos-Santos-SilvaDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Martine DumontGenomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Université Laval, Québec City, QC G1V 4G2, Canada.
Lorraine DurcanSouthampton Clinical Trials Unit, Faculty of Medicine, University of Southampton, Southampton SO17 6YD, UK; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton SO17 6YD, UK.
Miriam DwekSchool of Life Sciences, University of Westminster, London W1B 2HW, UK.
Diana M EcclesCancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton SO17 6YD, UK.
Arif B EkiciInstitute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen 91054, Germany.
A Heather EliassenChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
Carolina EllbergDepartment of Cancer Epidemiology, Clinical Sciences, Lund University, Lund 222 42, Sweden.
Christoph EngelInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig 04107, Germany; LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig 04103, Germany.
Mikael ErikssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 65, Sweden.
D Gareth EvansDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9WL, UK; North West Genomic Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, UK.
Peter A FaschingDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen 91054, Germany; David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Jonine FigueroaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20850, USA; Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh Medical School, Edinburgh EH16 4TJ, UK; Cancer Research UK Edinburgh Centre, Edinburgh EH4 2XR, UK.
Olivia FletcherThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW7 3RP, UK.
Henrik FlygerDepartment of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev 2730, Denmark.
Asta FörstiDivision of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö 205 02, Sweden.
Lin FritschiSchool of Public Health, Curtin University, Perth, WA 6102, Australia.
Marike GabrielsonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 65, Sweden.
Manuela Gago-DominguezGenomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela 15706, Spain; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Susan M GapsturEpidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA.
José A García-SáenzMedical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid 28040, Spain.
Mia M GaudetEpidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA.
Vassilios GeorgouliasDepartment of Medical Oncology, University Hospital of Heraklion, Heraklion 711 10, Greece.
Graham G GilesCancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, VIC 3004, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Irina R GilyazovaInstitute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa 450054, Russia; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa 450076, Russia.
Gord GlendonFred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Mark S GoldbergDepartment of Medicine, McGill University, Montréal, QC H4A 3J1, Canada; Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montréal, QC H4A 3J1, Canada.
David E GoldgarDepartment of Dermatology and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Anna González-NeiraHuman Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
Grethe I Grenaker AlnæsDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo 0379, Norway.
Mervi GripDepartment of Surgery, Oulu University Hospital, University of Oulu, Oulu 90220, Finland.
Jacek GronwaldDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin 71-252, Poland.
Anne GrundyCentre de Recherche du Centre Hospitalier de Université de Montréal (CHUM), Université de Montréal, Montréal, QC H2X 0A9, Canada.
Pascal GuénelCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif 94805, France.
Lothar HaeberleDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen 91054, Germany.
Eric HahnenCenter for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne 50937, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne 50931, Germany.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Niclas HåkanssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm 171 77, Sweden.
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Susan E HankinsonDepartment of Biostatistics & Epidemiology, University of Massachusetts, Amherst, Amherst, MA 1003, USA.
Elaine F HarknessDivision of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, UK; Nightingale Breast Screening Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, UK.
Steven N HartDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Wei HeDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 65, Sweden.
Alexander HeinDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen 91054, Germany.
Jane HeyworthSchool of Population and Global Health, University of Western Australia, Perth, WA 6009, Australia.
Peter HillemannsGynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany.
Antoinette HollestelleDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam 3015 CN, the Netherlands.
Maartje J HooningDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam 3015 CN, the Netherlands.
Robert N HooverDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20850, USA.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia.
Anthony HowellDivision of Cancer Sciences, University of Manchester, Manchester M13 9PL, UK.
Guanmengqian HuangMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Keith HumphreysDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 65, Sweden.
David J HunterDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA; Program in Genetic Epidemiology and Statistical Genetics, Harvard TH Chan School of Public Health, Boston, MA 02115, USA; Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
Milena JakimovskaResearch Centre for Genetic Engineering and Biotechnology "Georgi D. Efremov," Macedonian Academy of Sciences and Arts, Skopje 1000, Republic of Macedonia.
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin 71-252, Poland; Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin 71-252, Poland.
Wolfgang JanniDepartment of Gynecology and Obstetrics, University Hospital Ulm, Ulm 89075, Germany.
Esther M JohnDepartment of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94304, USA.
Nichola JohnsonThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW7 3RP, UK.
Michael E JonesDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK.
Arja Jukkola-VuorinenDepartment of Oncology, Tampere University Hospital, Tampere, Finland Box 2000, 33521 Tampere, Finland.
Audrey JungDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Katarzyna KaczmarekDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin 71-252, Poland.
Vesa KatajaTranslational Cancer Research Area, University of Eastern Finland, Kuopio 70210, Finland; Central Finland Health Care District, Jyväskylä Central Hospital, Jyväskylä 40620, Finland.
Renske KeemanDivision of Molecular Pathology, the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam 1066 CX, the Netherlands.
Michael J KerinSurgery, School of Medicine, National University of Ireland, Galway H91TK33, Ireland.
Elza KhusnutdinovaInstitute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa 450054, Russia; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa 450076, Russia.
Johanna I KiiskiDepartment of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki 00290, Finland.
Julia A KnightProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5T 3L9, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada.
Yon-Dschun KoDepartment of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn 53177, Germany.
Veli-Matti KosmaTranslational Cancer Research Area, University of Eastern Finland, Kuopio 70210, Finland; Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio 70210, Finland; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio 70210, Finland.
Stella KoutrosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20850, USA.
Vessela N KristensenDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo 0379, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo 0450, Norway.
Ute KrügerDepartment of Cancer Epidemiology, Clinical Sciences, Lund University, Lund 222 42, Sweden.
Tabea KühlCancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
Diether LambrechtsVIB Center for Cancer Biology, VIB, Leuven 3000, Belgium; Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven 3000, Belgium.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Eunjung LeeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Flavio LejbkowiczClalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa 35254, Israel.
Jenna LilyquistDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, and Department of Clinical Genetics, Karolinska University Hospital, Stockholm 171 76, Sweden.
Sara LindströmDepartment of Epidemiology, University of Washington School of Public Health, Seattle, WA 98195, USA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, M Sklodowska-Curie Cancer Center - Oncology Institute, Warsaw 02-034, Poland.
Wing-Yee LoDr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart 70376, Germany; University of Tübingen, Tübingen 72074, Germany.
Sibylle LoiblGerman Breast Group, GmbH, Neu Isenburg 63263, Germany.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Jan LubińskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin 71-252, Poland.
Michael P LuxDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen 91054, Germany.
Robert J MacInnisCancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, VIC 3004, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia.
Tom MaishmanSouthampton Clinical Trials Unit, Faculty of Medicine, University of Southampton, Southampton SO17 6YD, UK; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton SO17 6YD, UK.
Enes MakalicCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia.
Ivana Maleva KostovskaResearch Centre for Genetic Engineering and Biotechnology "Georgi D. Efremov," Macedonian Academy of Sciences and Arts, Skopje 1000, Republic of Macedonia.
Arto MannermaaTranslational Cancer Research Area, University of Eastern Finland, Kuopio 70210, Finland; Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio 70210, Finland; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio 70210, Finland.
Siranoush ManoukianUnit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan 20133, Italy.
Sara MargolinDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm 118 83, Sweden; Department of Oncology, Södersjukhuset, Stockholm 118 83, Sweden.
John W M MartensDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam 3015 CN, the Netherlands.
Maria Elena MartinezMoores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA; Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA 92093, USA.
Dimitrios MavroudisDepartment of Medical Oncology, University Hospital of Heraklion, Heraklion 711 10, Greece.
Catriona McLeanAnatomical Pathology, The Alfred Hospital, Melbourne, VIC 3004, Australia.
Alfons MeindlDepartment of Gynecology and Obstetrics, Ludwig Maximilian University of Munich, Munich 80336, Germany.
Usha MenonMRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London WC1V 6LJ, UK.
Pooja MiddhaDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; Faculty of Medicine, University of Heidelberg, Heidelberg 69120, Germany.
Nicola MillerSurgery, School of Medicine, National University of Ireland, Galway H91TK33, Ireland.
Fernando MorenoMedical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid 28040, Spain.
Anna Marie MulliganDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Laboratory Medicine Program, University Health Network, Toronto, ON M5G 2C4, Canada.
Claire MulotUniversité Paris Sorbonne Cité, INSERM UMR-S1147, Paris 75270, France.
Victor M Muñoz-GarzonRadiation Oncology, Hospital Meixoeiro-XXI de Vigo, Vigo 36214, Spain.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki 00290, Finland.
Patrick NevenLeuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven 3000, Belgium.
William G NewmanDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9WL, UK; North West Genomic Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, UK.
Sune F NielsenCopenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev 2730, Denmark; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev 2730, Denmark.
Børge G NordestgaardCopenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev 2730, Denmark; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev 2730, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Aaron NormanDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Kenneth OffitClinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Janet E OlsonDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Håkan OlssonDepartment of Cancer Epidemiology, Clinical Sciences, Lund University, Lund 222 42, Sweden.
Nick OrrCentre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast BT7 1NN, UK.
V Shane PankratzUniversity of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NM 87131, USA.
Tjoung-Won Park-SimonGynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany.
Jose I A PerezServicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo 33012, Spain.
Clara Pérez-BarriosMedical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid 28222, Spain.
Paolo PeterlongoGenome Diagnostic Program, IFOM the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan 20139, Italy.
Julian PetoDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Mila PinchevClalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa 35254, Israel.
Dijana Plaseska-KaranfilskaResearch Centre for Genetic Engineering and Biotechnology "Georgi D. Efremov," Macedonian Academy of Sciences and Arts, Skopje 1000, Republic of Macedonia.
Eric C PolleyDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Ross PrenticeCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Nadege PresneauSchool of Life Sciences, University of Westminster, London W1B 2HW, UK.
Darya ProkofyevaDepartment of Genetics and Fundamental Medicine, Bashkir State University, Ufa 450076, Russia.
Kristen PurringtonDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Katri PylkäsLaboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu 90220, Finland; Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu 90220, Finland.
Brigitte RackDepartment of Gynecology and Obstetrics, University Hospital Ulm, Ulm 89075, Germany.
Paolo RadiceUnit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan 20133, Italy.
Rohini Rau-MurthyClinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Gad RennertClalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa 35254, Israel.
Hedy S RennertClalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa 35254, Israel.
Valerie RheniusCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Mark RobsonClinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Atocha RomeroMedical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid 28222, Spain.
Kathryn J RuddyDepartment of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Matthias RuebnerDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen 91054, Germany.
Emmanouil SaloustrosDepartment of Oncology, University Hospital of Larissa, Larissa 711 10, Greece.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.
Elinor J SawyerResearch Oncology, Guy's Hospital, King's College London, London SE1 9RT, UK.
Daniel F SchmidtCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia; Faculty of Information Technology, Monash University, Melbourne, VIC 3800, Australia.
Rita K SchmutzlerCenter for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne 50937, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne 50931, Germany.
Andreas SchneeweissNational Center for Tumor Diseases, University Hospital and German Cancer Research Center, Heidelberg 69120, Germany.
Minouk J SchoemakerDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK.
Fredrick SchumacherDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Peter SchürmannGynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany.
Lukas SchwentnerDepartment of Gynecology and Obstetrics, University Hospital Ulm, Ulm 89075, Germany.
Christopher ScottDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Rodney J ScottDivision of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, NSW 2305, Australia; Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2305, Australia.
Caroline SeynaeveDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam 3015 CN, the Netherlands.
Mitul ShahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Mark E ShermanDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
Martha J ShrubsoleDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Susan SlagerDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Ann SmeetsLeuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven 3000, Belgium.
Christof SohnNational Center for Tumor Diseases, University Hospital and German Cancer Research Center, Heidelberg 69120, Germany.
Penny SoucyGenomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Université Laval, Québec City, QC G1V 4G2, Canada.
Melissa C SoutheyPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC 3168, Australia; Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia.
John J SpinelliPopulation Oncology, BC Cancer, Vancouver, BC V5Z 1G1, Canada; School of Population and Public Health, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
Christa StegmaierSaarland Cancer Registry, Saarbrücken 66119, Germany.
Jennifer StoneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia; The Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Perth, WA 6000, Australia.
Anthony J SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK; Division of Breast Cancer Research, The Institute of Cancer Research, London SW7 3RP, UK.
Rulla M TamimiChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA; Program in Genetic Epidemiology and Statistical Genetics, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
William J TapperFaculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK.
Jack A TaylorEpidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA; Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.
Mary Beth TerryDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Kathrin ThöneCancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
Rob A E M TollenaarDepartment of Surgery, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands.
Ian TomlinsonInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK; Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK.
Thérèse TruongCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif 94805, France.
Maria TzardiDepartment of Pathology, University Hospital of Heraklion, Heraklion 711 10, Greece.
Hans-Ulrich UlmerFrauenklinik der Stadtklinik Baden-Baden, Baden-Baden 76532, Germany.
Michael UntchDepartment of Gynecology and Obstetrics, Helios Clinics Berlin-Buch, Berlin 13125, Germany.
Celine M VachonDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Elke M van VeenDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9WL, UK; North West Genomic Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, UK.
Joseph VijaiClinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Clarice R WeinbergBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.
Camilla WendtDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm 118 83, Sweden; Department of Oncology, Södersjukhuset, Stockholm 118 83, Sweden.
Alice S WhittemoreDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA 94305, USA.
Hans WildiersLeuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven 3000, Belgium.
Walter WillettDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Robert WinqvistLaboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu 90220, Finland; Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu 90220, Finland.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm 171 77, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala 751 05, Sweden.
Xiaohong R YangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20850, USA.
Drakoulis YannoukakosMolecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos," Athens 15310, Greece.
Yan ZhangDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Argyrios ZiogasDepartment of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA 92617, USA.
ABCTB InvestigatorsAustralian Breast Cancer Tissue Bank, Westmead Institute for Medical Research, University of Sydney, Sydney, NSW 2145, Australia.
kConFab/AOCS InvestigatorsPeter MacCallum Cancer Center, Melbourne, VIC 3000, Australia.
NBCS CollaboratorsDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo 0379, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo 0450, Norway; Department of Research, Vestre Viken Hospital, Drammen 3019, Norway; Department of Cancer Genetics, Vestre Viken Hospital, Drammen 3019, Norway; Section for Breast and Endocrine Surgery, Department of Cancer, Division of Surgery, Cancer and Transplantation Medicine, Oslo University Hospital-Ullevål, Oslo 0450, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo 0379, Norway; Department of Pathology, Akershus University Hospital, Lørenskog 1478, Norway; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo 0379, Norway; Department of Oncology, Division of Surgery, Cancer and Transplantation Medicine, Oslo University Hospital-Radiumhospitalet, Oslo 0379, Norway; National Advisory Unit on Late Effects after Cancer Treatment, Oslo University Hospital-Radiumhospitalet, Oslo 0379, Norway; Department of Oncology, Akershus University Hospital, Lørenskog 1478, Norway; Breast Cancer Research Consortium, Oslo University Hospital, Oslo 0379, Norway.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Deborah J ThompsonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Georgia Chenevix-TrenchDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
Marjanka K SchmidtDivision of Molecular Pathology, the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam 1066 CX, the Netherlands; Division of Psychosocial Research and Epidemiology, the Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam 1066 CX, the Netherlands.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 65, Sweden; Department of Oncology, Södersjukhuset, Stockholm 118 83, Sweden.
Roger L MilneCancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, VIC 3004, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC 3168, Australia.
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Antonis C AntoniouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Nilanjan ChatterjeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20850, USA; Department of Biostatistics, Bloomberg School of Public Health, John Hopkins University, Baltimore, MD 21205, USA; Department of Oncology, School of Medicine, John Hopkins University, Baltimore, MD 21205, USA.
Peter KraftDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA; Program in Genetic Epidemiology and Statistical Genetics, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
Montserrat García-ClosasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20850, USA.
Jacques SimardGenomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Université Laval, Québec City, QC G1V 4G2, Canada.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI PETER C LUCAS · 2005 to 2026
$49.9M
Environmental and Genetic Risk Factors For Breast Cancer: The Sister StudyZIAES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2025
$22.7M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
The Two Sister StudyZIAES102245 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WEINBERG, CLARICE · 2009 to 2025
$8.6M
Genetic Susceptibility And The Environment In Cancer RiskZIAES049033 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI TAYLOR, JACK A · 2009 to 2022
$7.7M
Mayo Cancer Genetic Epidemiology Training ProgramR25CA092049 · NCI · MAYO CLINIC ROCHESTER · PI PETERSEN, GLORIA M., VACHON, CELINE M · 2001 to 2018
$5.3M
Cancer Research UK 10118Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 15956Cancer Research UK 16459Cancer Research UK 16561Cancer Research UK 16563Cancer Research UK 19187Cancer Research UK 20861Cancer Research UK 25352Cancer Research UK C1287/A10710Cancer Research UK C1287/A16563Department of Health RP-PG-0707-10031Department of Health RP-PG-1214-20016Medical Research Council MC_PC_12028Medical Research Council MC_PC_14105Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/P012930/1NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA116201NCI NIH HHS R25 CA092049NCI NIH HHS U19 CA148065
6 · The paper itself

Abstract

Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divided into training and validation sets. Samples were genotyped using genome-wide arrays, and single-nucleotide polymorphisms (SNPs) were selected by stepwise regression or lasso penalized regression. The best performing PRSs were validated in an independent test set comprising 11,428 case subjects and 18,323 control subjects from 10 prospective studies and 190,040 women from UK Biobank (3,215 incident breast cancers). For the best PRSs (313 SNPs), the odds ratio for overall disease per 1 standard deviation in ten prospective studies was 1.61 (95%CI: 1.57-1.65) with area under receiver-operator curve (AUC) = 0.630 (95%CI: 0.628-0.651). The lifetime risk of overall breast cancer in the top centile of the PRSs was 32.6%. Compared with women in the middle quintile, those in the highest 1% of risk had 4.37- and 2.78-fold risks, and those in the lowest 1% of risk had 0.16- and 0.27-fold risks, of developing ER-positive and ER-negative disease, respectively. Goodness-of-fit tests indicated that this PRS was well calibrated and predicts disease risk accurately in the tails of the distribution. This PRS is a powerful and reliable predictor of breast cancer risk that may improve breast cancer prevention programs.

Indexed as

Genetic Predisposition to DiseaseAdultAgedAged, 80 and overAge FactorsBreast NeoplasmsFemaleHumansMedical History TakingMiddle AgedMultifactorial InheritancePolymorphism, Single NucleotideReceptors, EstrogenReproducibility of ResultsRisk AssessmentReceptors, Estrogenbreastcancerepidemiologygeneticpolygenicpredictionriskscorescreeningstratification

Identifiers

PMID30554720
PMCPMC6323553

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