ArticleAmerican journal of respiratory and critical care medicine2019
Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.
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In one paragraph
Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 826 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
826citing papers in PubMed, 2 pooled it
100.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
826 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,246 citations in OpenAlex.
- Transcriptomics of interstitial lung disease: a systematic review and meta-analysis.The European respiratory journal · 2025Pooled it
- Targeted therapy for idiopathic pulmonary fibrosis: a bibliometric analysis of 2004-2024.Frontiers in medicine · 2025Pooled it
- Design of the MERCURION-IPF trial - intravenous immunoglobulin for the treatment of acute exacerbations of idiopathic pulmonary fibrosis.Frontiers in immunology · 2026Trial
- Acute exacerbation in fibrotic interstitial lung disease: an international working group report.American journal of respiratory and critical care medicine · 2026Review
- Alveolar Macrophages: Development, Respiratory Homeostasis, Signal Pathways, Diseases, and Therapeutic Opportunities.MedComm · 2026Review
- Transcriptional factor KLF9 in pulmonary fibrosis: from molecular mechanisms to precision intervention-a narrative review.Journal of thoracic disease · 2026Review
- Peripheral immune checkpoint gene expression as diagnostic biomarkers in idiopathic pulmonary fibrosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2026Article
- Mechanosignaling promotes macrophage apoptosis resistance in pulmonary fibrosisbioRxiv : the preprint server for biology · 2026Article
- Article
- PAX5 modulates vascularization and contributes to neuroendocrine lineage transition during carcinoma progression.The Journal of clinical investigation · 2026Article
- A2BAR Antagonism Mitigates Pulmonary Inflammation and Fibrosis and Restores Macrophage M1/M2 Balance in Diabetic Rats.International journal of molecular sciences · 2026Article
- mExperimental and therapeutic medicine · 2026Review
- Angiogenesis in Lung Regeneration and Aging.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Non-Resolving Repair in Idiopathic Pulmonary Fibrosis: From Failed Cellular Transitions to Architectural Lock-In.International journal of molecular sciences · 2026Review
- Transcriptomic signatures of IPF in ALI-cultured airway cells and their therapeutic implications.Thorax · 2026Article
- IDEAL-Age: an interpretable deep learning framework for single-cell resolution profiling of immunological aging.Genome biology · 2026Article
- Alveolar Epithelial Cell Loss of the Mitochondrial Regulator TFAM Drives Progressive Lung Fibrosis.bioRxiv : the preprint server for biology · 2026Article
- Article
- Cellular hallmarks and aging clock of the human lung parenchyma.Nature communications · 2026Article
- Next-Generation Sequencing in Pulmonary Fibrosis: Translational Promise and Current Clinical Limitations.Current issues in molecular biology · 2026Review
766 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
49 authors at 6 institutions in 1 country.
Paul A Reyfman1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.ORCID 0000-0002-6435-6001
James M Walter1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.ORCID 0000-0001-7428-3101
Nikita Joshi1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.ORCID 0000-0001-8330-0663
Kishore R Anekalla1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.ORCID 0000-0002-8366-5782
Alexandra C McQuattie-Pimentel1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Stephen Chiu2 Division of Thoracic Surgery, Department of Surgery.
Ramiro Fernandez2 Division of Thoracic Surgery, Department of Surgery.
Mahzad Akbarpour2 Division of Thoracic Surgery, Department of Surgery.
Ching-I Chen1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Ziyou Ren1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Rohan Verma1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Hiam Abdala-Valencia1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Kiwon Nam1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Monica Chi1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
SeungHye Han1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Francisco J Gonzalez-Gonzalez1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Saul Soberanes1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Satoshi Watanabe1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Kinola J N Williams1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Annette S Flozak1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Trevor T Nicholson1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Vince K Morgan3 Division of Rheumatology, Department of Medicine.
Deborah R Winter3 Division of Rheumatology, Department of Medicine.
Monique Hinchcliff3 Division of Rheumatology, Department of Medicine.
Cara L Hrusch4 Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois; and.
Robert D Guzy4 Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois; and.
Catherine A Bonham4 Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois; and.
Anne I Sperling4 Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois; and.
Remzi Bag4 Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois; and.
Robert B Hamanaka4 Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois; and.ORCID 0000-0002-8909-356X
Gökhan M Mutlu4 Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois; and.
Anjana V Yeldandi5 Department of Pathology, and.
Stacy A Marshall6 Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Ali Shilatifard6 Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Luis A N Amaral7 Department of Chemical and Biological Engineering, Weinberg College of Arts and Sciences, Northwestern University, Evanston, Illinois.
Harris Perlman3 Division of Rheumatology, Department of Medicine.
Jacob I Sznajder1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
A Christine Argento1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Colin T Gillespie1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Jane Dematte1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Manu Jain1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Benjamin D Singer1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.ORCID 0000-0001-5775-8427
Karen M Ridge1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Anna P Lam1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Ankit Bharat2 Division of Thoracic Surgery, Department of Surgery.
Sangeeta M Bhorade1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
Cara J Gottardi1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.
G R Scott Budinger1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.ORCID 0000-0002-3114-5208
Alexander V Misharin1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.ORCID 0000-0003-2879-3789
Pulmonary and Critical Care Associates · USUniversity of Chicago · USCenter for Rheumatology · USNorthwestern University · USThoracic Surgery Foundation · USPediatrics and Genetics · US
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MNorthwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8MRole of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHANDEL, NAVDEEP S · 2003 to 2019
$30.8MTissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2015 to 2026
$26.9MTechnology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RICHARD G WUNDERINK · 2018 to 2026
$24.7MTraining Program In Lung SciencesT32HL076139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE, Jacob I Sznajder · 2004 to 2026
$9.6MRole of alveolar macrophages in particulate matter-induced cardiopulmonary diseaseR01ES015024 · NIEHS · UNIVERSITY OF CHICAGO · PI MUTLU, GOKHAN M. · 2006 to 2022
$6.1MThe injurious effects of hypercapnia on the alveolar epitheliumR01HL085534 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2006 to 2018
$4.9MRole and Regulation of Sodium, Potasium ATPase in LungR37HL048129 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2008 to 2017
$4.0MSignaling in the lung induced by particulate matter air pollutionR01ES013995 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BUDINGER, GR SCOTT · 2006 to 2015
$3.3MWnt-beta-catenin cross interactions in alveolar macrophages and epithelial cells in persistence of SSc-ILDR01HL134800 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOTTARDI, CARA J · 2018 to 2021
$2.9MBLRD VA I01 BX000201CSRD VA I01 CX001777NCATS NIH HHS UL1 TR001422NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA060553NHLBI NIH HHS F32 HL136111NHLBI NIH HHS K08 HL125910NHLBI NIH HHS K08 HL125940NHLBI NIH HHS K08 HL128867NHLBI NIH HHS K12 HL119995NHLBI NIH HHS K23 HL143135NHLBI NIH HHS L30 HL134087NHLBI NIH HHS P01 HL071643NHLBI NIH HHS R01 HL048129NHLBI NIH HHS R01 HL085534NHLBI NIH HHS R01 HL128194NHLBI NIH HHS R01 HL134375NHLBI NIH HHS R01 HL134800NHLBI NIH HHS R37 HL048129NHLBI NIH HHS R56 HL127245NHLBI NIH HHS R56 HL135124NHLBI NIH HHS T32 HL076139NIAID NIH HHS R21 AI126031NIAID NIH HHS U19 AI135964NIAMS NIH HHS K01 AR066579NIAMS NIH HHS R01 AR064546NIAMS NIH HHS UH2 AR067687NIA NIH HHS P01 AG049665NIEHS NIH HHS R01 ES013995NIEHS NIH HHS R01 ES015024NIEHS NIH HHS R21 ES025644NIH HHS S10 OD010398NIH HHS S10 OD011996
Abstract
PubMed holds no abstract for this paper.
Indexed as
Sequence Analysis, RNATranscriptomeAnimalsCells, CulturedDisease Models, AnimalEpithelial CellsFemaleHumansIdiopathic Pulmonary FibrosisMaleStem Cellsalveolar macrophagesalveolar type II cellspulmonary fibrosisRNA sequencing
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.