Evidence map›Paper›PMID 30554358›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2019

Updated Sniffin' Sticks normative data based on an extended sample of 9139 subjects.

A Oleszkiewicz, V A Schriever, I Croy, A Hähner, Thomas Hummel

Registry-linked trialAbstract read
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05461365 (Intranasal Insulin for COVID-19-related Smell Loss), which is not on this map. Cited by 355 papers.

0numbers the graph read from it
0cells of the map it votes in
355citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05461365 phase3completednot on this mapstarted 2021, after this paper: background citation

Intranasal Insulin for COVID-19-related Smell Loss

TypeinterventionalSponsorUniversidad PanamericanaRan2021 to 2021Enrolled27ConditionsAnosmia, Smell Loss, Paraosmia, HyposmiaArmsInsulin
3 · Its place in the literature

Who cites it

355 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Treatment of COVID-19 olfactory dysfunction with olfactory training, palmitoylethanolamide with luteolin, or combined therapy: a blinded controlled multicenter randomized trial.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Trial
  6. Retronasal Olfactory Function After Olfactory Training: A Prospective Single-Arm Study.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026
    Article
  7. Article
  8. Article
  9. A new framework for the labeling of odors in the Sniffin' Sticks odor identification test: relevance of familiarity and test-retest assessment.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  10. Article
  11. Blood biomarkers for the prediction of idiopathic taste dysfunction: a case-control study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Isolated Fractures of the Nose Are Associated with Olfactory Impairment.ORL; journal for oto-rhino-laryngology and its related specialties · 2026
    Article
  16. Enhanced detection of respiratory pathogens in olfactory swabs correlates with olfactory dysfunction in chronic rhinosinusitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  17. Review
  18. Article
  19. Article
  20. Article

295 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A OleszkiewiczDepartment of Otorhinolaryngology, Smell and Taste Clinic, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.ORCID http://orcid.org/0000-0003-2217-1858
V A SchrieverDepartment of Neuropediatric Medicine, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
I CroyDepartment of Psychotherapy and Psychosomatic Medicine, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
A HähnerDepartment of Otorhinolaryngology, Smell and Taste Clinic, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
Thomas HummelDepartment of Otorhinolaryngology, Smell and Taste Clinic, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany. thummel@mail.zih.tu-dresden.de.

Funding

Deutsche Forschungsgemeinschaft DFG HU 411/18-1Ministerstwo Nauki i Szkolnictwa Wyższego 626/STYP/12/2017
6 · The paper itself

Abstract

purposeTo provide up-to-date and detailed normative data based on a large-scale sample, increasing diagnostic validity by reference to narrow age groups as previous normative values were based upon smaller sample sizes-especially in the group of older subjects.

methodData were obtained from 9139 healthy subjects (4928 females aged 5-96 years and 4211 males aged 5-91 years). The standard "Sniffin' Sticks" test was applied, comprising threshold (T), discrimination (D) and identification (I) subtests, and yielding a TDI sum score.

resultsHyposmia was established at a TDI score of less than 30.75. Age-related changes were found in each domain, most pronounced for thresholds. Individuals aged 20-30 years performed best, whereas children below the age of 10 and adults above the age of 71 scored only half as well. Sex-related differences were in favor of women.

conclusionsData provide guidance for assessing individual olfactory performance in relation to specific age groups. Significant gender and age effects were observed, with a most pronounced increase of olfactory test scores between age 5 through 20 years and a dramatic decrease at the age of 60 through 71 years.

Indexed as

OdorantsAdolescentAdultAgedAged, 80 and overAge FactorsChildChild, PreschoolFemaleHealthy VolunteersHumansMaleMiddle AgedOlfaction DisordersSensory ThresholdsSex FactorsDiscriminationIdentificationNormative dataOlfactionSniffin’ SticksThreshold

Identifiers

PMID30554358
PMCPMC6411676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.