Evidence map›Paper›PMID 30554325›Full record

ArticleEating and weight disorders : EWD2020

Unhealthy lifestyle and oxidative damage in childhood obesity.

Rachele De Giuseppe, Valeria Calcaterra, Ginevra Biino, Matteo Manuelli, Noelia Rodriguez Mier, Melissa Mantelli, Maria De Filippo, Gianguido Cossellu, Hellas Cena

Abstract read
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In one paragraph

Article in Eating and weight disorders : EWD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Rachele De GiuseppeDietetics and Clinical Nutrition Laboratory, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
Valeria CalcaterraDepartment of Maternal and Children's Health, Pediatric Endocrinology Unit, Fondazione IRCCS Policlinico S. Matteo, P.le Golgi n.2, 27100, Pavia, Italy. v.calcaterra@smatteo.pv.it.ORCID http://orcid.org/0000-0002-2137-5974
Ginevra BiinoInstitute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.
Matteo ManuelliDietetics and Clinical Nutrition Laboratory, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
Noelia Rodriguez MierDietetics and Clinical Nutrition Laboratory, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
Melissa MantelliImmunology and Transplantation Laboratory/Cell Factory/Pediatric Hematology/Oncology Department, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.
Maria De FilippoDepartment of Maternal and Children's Health, Pediatric Endocrinology Unit, Fondazione IRCCS Policlinico S. Matteo, P.le Golgi n.2, 27100, Pavia, Italy.
Gianguido CosselluDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milano, Italy.
Hellas CenaDietetics and Clinical Nutrition Laboratory, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
University of Pavia · ITNational Research Council · ITPoliclinico San Matteo Fondazione · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOxidized LDL cholesterol (oxLDL) has been considered as a sensor of oxidative stress (OS) in childhood obesity. We integrated and related our oxLDL existing results previously assessed in overweight/obese children to lifestyle variables to investigate OS-related lifestyle variables.

methods178 Caucasian children/adolescents have been evaluated and according to BMI percentiles have been classified as normal weight (BMI < 75th); overweight (BMI 75-97th) and obese (BMI > 97th). Serum oxLDL levels have been measured. The dietary habits and physical activity have been also assessed.

resultsNo differences between normal weight and overweight/obese children were detected according to the total score of dietary habits section. Normal weight subjects reported a higher total physical activity score (p = 0.001) compared to overweight/ obese children. No correlation between oxLDL and total dietary habits and physical activity scores was noted. Increased oxLDL in subjects drinking < 1 L/day of water (p = 0.022) and in daily consumers of chocolate drinks at breakfast (p = 0.029) was observed, while a decreased oxLDL was reported in subjects consuming a breakfast based mainly on fruits (p = 0.004). Moreover, "high-fat diet" and "always eating a dessert at the end of the meal" were correlated with increased oxLDL with a trend towards significance. As regards physical activity, no correlations were observed.

conclusionsDiet and physical activity may not have an immediate impact on OS response in children with or without obesity. Unhealthy lifestyle, including increased fat, simple sugar intake, poor water intake, emerged as external exposome predictors of OS, that may be monitored to improve health status. LEVEL OF EVIDENCE: Level III, case-control analytic studies.

Indexed as

DietExerciseLife StyleOxidative StressAdolescentChildDietary SugarsDiet, High-FatDrinking BehaviorDrinking WaterExposomeFemaleFruitHumansLipoproteins, LDLMaleDietary SugarsDrinking WaterLipoproteins, LDLoxidized low density lipoproteinChildhood obesityDietary habitsOxidative damagePhysical activityUnhealthy lifestyle

Identifiers

PMID30554325
OpenAlexW2904096903

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.