Evidence map›Paper›PMID 30554324›Full record

Observational studySleep & breathing = Schlaf & Atmung2019

Association between REM sleep and obstructive sleep apnea in obese and overweight adolescents.

Orna Sever, Eric J Kezirian, Emily Gillett, Sally L Davidson Ward, Michael Khoo, Iris A Perez

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Sleep & breathing = Schlaf & Atmung, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. [Comparative Study of Clinical Manifestations and Sleep Structure in Children with Obstructive Sleep Apnea-hypopnea Syndrome with Different BMI].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2021
    Article
  5. Clinical features of obstructive sleep apnea in children with obesity.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Orna SeverChildren's Hospital Los Angeles, 4650 Sunset Blvd., #83, Los Angeles, CA, USA.
Eric J KezirianKeck School of Medicine of USC, Los Angeles, CA, USA.
Emily GillettChildren's Hospital Los Angeles, 4650 Sunset Blvd., #83, Los Angeles, CA, USA.
Sally L Davidson WardChildren's Hospital Los Angeles, 4650 Sunset Blvd., #83, Los Angeles, CA, USA.
Michael KhooViterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Iris A PerezChildren's Hospital Los Angeles, 4650 Sunset Blvd., #83, Los Angeles, CA, USA. iaperez@chla.usc.edu.
Keck Hospital of USC · USChildren's Hospital of Los Angeles · USUniversity of Southern California · US

Funding

Children's Hospital Los Angeles General Clinical Research Center M01 RR00047; RO1-HL-105210National Institutes of Health EB001978National Institutes of Health HL090451University of Southern California Center for Transdisciplinary Research on Energetics and Cancer TREC U54 CA 116848
6 · The paper itself

Abstract

purposeOverweight and obese children have demonstrated reduced rapid eye movement (REM) sleep, affecting energy balance regulation and predisposition to weight gain. Obstructive sleep apnea (OSA) is a known cause of decreased REM sleep. The purpose of this study is to examine the association between the percentage of REM sleep, BMI z-score, and OSA severity in overweight and obese adolescents.

methodsWe performed a cross-sectional study of 92 (43% female) overweight and obese adolescents (13-17 years old) who underwent overnight polysomnography (PSG) at Children's Hospital Los Angeles between 2010 and 2017.

resultsThe average Body Mass Index (BMI) z-score was 2.27 ± 0.47, with 71% having BMI z-score ≥ 2. REM% during PSG was 15.6 ± 6.8, and obstructive apnea-hypopnea index was 17.1 ± 24.3. The distribution across categories of OSA severity was 27% none (≤ 1.5 events/h), 24% mild (> 1.5-5 events/h), 8% moderate (> 5-10 events/h), and 41% severe (> 10 events/h). REM% was not associated with BMI z-score, either on univariate or multivariate regression with adjustment for age, gender, and apnea-hypopnea index (AHI). When subdivided into OSA categories, a 1-unit increase in BMI z-score was associated with a 5.96 (p = 0.03) increase in REM% in mild OSA and an 8.86 (p = 0.02) decrease in REM% in severe OSA. There was no association between BMI z-score and REM% in none and moderate OSA.

conclusionAmong overweight and obese adolescents, BMI z-score was associated with decreased REM% in severe OSA and unexpectedly increased REM% in mild OSA, but there was no association in none or moderate OSA.

Indexed as

Sleep, REMAdolescentBody Mass IndexCross-Sectional StudiesFemaleHospitals, PediatricHumansLos AngelesMaleObesityOverweightPolysomnographyRetrospective StudiesRisk FactorsSleep Apnea, ObstructiveAdolescentsObesityObstructive sleep apneaRapid eye movement

Identifiers

PMID30554324
OpenAlexW2904960998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.