Evidence map›Paper›PMID 30554285›Full record

ArticleInternational journal of clinical oncology2019

Interaction of H. pylori with toll-like receptor 2-196 to -174 ins/del polymorphism is associated with gastric cancer susceptibility in southern China.

Jin Huang, Jun-Jie Hang, Xiang-Rong Qin, Jian Huang, Xiao-Yong Wang

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of clinical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. The immunopathogenesis ofFrontiers in microbiology · 2024
    Review
  3. Review
  4. Article
  5. Characterization and strong risk association ofWorld journal of gastrointestinal oncology · 2020
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jin HuangDepartment of Gastroenterology, Changzhou No. 2 People's Hospital, Xinglong Xiang 29, Changzhou, 213000, Jiangsu, China.
Jun-Jie HangDepartment of Oncology, Changzhou No. 2 People's Hospital, Xinglong Xiang 29, Changzhou, 213000, China.
Xiang-Rong QinDepartment of Gastroenterology, Changzhou No. 2 People's Hospital, Xinglong Xiang 29, Changzhou, 213000, Jiangsu, China.
Jian HuangDepartment of Gastroenterology, Changzhou No. 2 People's Hospital, Xinglong Xiang 29, Changzhou, 213000, Jiangsu, China.
Xiao-Yong WangDepartment of Gastroenterology, Changzhou No. 2 People's Hospital, Xinglong Xiang 29, Changzhou, 213000, Jiangsu, China. wxy20009@126.com.ORCID http://orcid.org/0000-0001-8401-4888
Changzhou No.2 People's Hospital · CN

Funding

the Applied Basic Research Fund of Changzhou, China CJ20140022the Applied Basic Research Fund of Changzhou, China CJ20179034the High-level Medicine Talents Training Project 2016CZBJ022the Youth Science and Technology Project of Changzhou Health and Family Planning Commission QN201601Young medical talents of Jiangsu province QNRC2016269
6 · The paper itself

Abstract

backgroundGenetic polymorphisms of Toll-like receptors play important roles in gastric carcinogenesis. The aim of this study was to determine the role of TLR2-196 to -174 ins/del polymorphism in gastric cancer susceptibility and prognosis.

methodsThis study included 520 people from southern China. Samples were genotyped by the allele-specific polymerase chain reaction, among which 10% were randomly selected for sequencing. The serological method was used to determine Helicobacter pylori.

resultsThe TLR2 genotype was not associated with the risk of H. pylori infection. The del/del genotype exhibited significantly higher gastric cancer risk (adjusted OR 2.59, 95% CI 1.33‒5.07) than that of the ins/ins genotype. Further stratification analyses demonstrated that the del/del genotype was associated with a risk of intestinal gastric cancer (adjusted OR 2.62, 95% CI 1.34-5.14). In addition, the presence of the del/del genotype and the H. pylori infection conferred a synergistic effect (OR 3.04, 95% CI 1.33‒6.98) for the development of gastric cancer. The del/del genotype was not associated with a poor prognosis in gastric cancer patients.

conclusionThe del/del genotype is associated with an increased gastric cancer risk in the southern Chinese population. However, TLR2 polymorphism is neither associated with H. pylori infection, nor with a poor prognosis.

Indexed as

Polymorphism, GeneticAdenocarcinomaAgedAsian PeopleCase-Control StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseHelicobacter InfectionsHelicobacter pyloriHumansMaleMiddle AgedPolymerase Chain ReactionPrognosisStomach NeoplasmsTLR2 protein, humanToll-Like Receptor 2Gastric cancerH. pyloriPolymorphismPrognosisTLR2

Identifiers

PMID30554285
OpenAlexW2905272245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.