ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019
Late systemic symptoms in head and neck cancer survivors.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Symptom Clusters in Head and Neck Cancer: A Systematic Review and Conceptual Model.Seminars in oncology nursing · 2021Pooled it
- Associations between MoCA screening-positive cognitive impairment, anxiety, depression, and quality of life in patients with oral cancer: a cross-sectional study in China.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- The Role of Dysphagia on Head and Neck Cancer Patients' Quality of Life, Functional Disabilities and Psychological Distress: Outcomes of Cancer Rehabilitation from an Observational Single-Center Study.Current oncology (Toronto, Ont.) · 2025Observational
- Review
- PRO-Based Stratification Improves Model Prediction for Toxicity and Survival of Head and Neck Cancer Patients.IEEE journal of biomedical and health informatics · 2025Article
- Benefit-finding in children with advanced cancer and their parents.Palliative & supportive care · 2024Article
- Qualitative Classification of Late Systemic Symptoms in Head and Neck Cancer Survivors.Cancers · 2024Article
- Associations between patient-reported late effects and systemic cytokines in long-term survivors of head and neck cancer treated with radiotherapy.Journal of cancer survivorship : research and practice · 2023Article
- Symptom Cluster Experiences of Patients Operated for Oral Cancer: A Mixed Methods Study.Seminars in oncology nursing · 2023Article
- On a pathway to resigned acceptance: Patients' experiences of living with symptom clusters in oral cancer.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2023Article
- Update on Prevalence of Pain in Patients with Cancer 2022: A Systematic Literature Review and Meta-Analysis.Cancers · 2023Review
- Quality of Life, Psychological Distress, and Nutritional Status of Polish Patients with Head and Neck Cancer Treated with Radiotherapy.Journal of clinical medicine · 2023Article
- Validity Testing of the Head and Neck Lymphedema and Fibrosis Symptom Inventory.Lymphatic research and biology · 2022Article
- Article
- Neuropsychiatric Disorders and Frailty in Older Adults over the Spectrum of Cancer: A Narrative Review.Cancers · 2022Review
- Mechanisms of pain and their manifestations in head and neck cancer: Importance of classifying pain subtypes.Head & neck · 2021Article
- The Psychosocial Role of Body Image in the Quality of Life of Head and Neck Cancer Patients. What Does the Future Hold?-A Review of the Literature.Medicina (Kaunas, Lithuania) · 2021Review
- Identifying Patient-Reported Outcome Measures (PROMs) for Routine Surveillance of Physical and Emotional Symptoms in Head and Neck Cancer Populations: A Systematic Review.Journal of clinical medicine · 2021Review
- Body mass index and self-care behaviors related to oral health-related quality of life in patients with oral squamous cell carcinoma within three months posttreatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Refinement and Validation of the Head and Neck Lymphedema and Fibrosis Symptom Inventory.International journal of radiation oncology, biology, physics · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNeuroinflammation and central sensitization from cancer and its therapy may result in chronic systemic symptoms (CSS) such as fatigue, sleep disturbance, chronic widespread pain, mood disorders, neuropsychiatric symptoms, and temperature dysregulation. We undertook a cross-sectional study of CSS in head and neck cancer (HNC) survivors to determine their frequency, severity, and impact.
methodsHNC patients without evidence of recurrence who were at least 12 months post-treatment completed a one-time battery of self-report measures including the Vanderbilt Head and Neck Symptom survey plus the General Symptom Subscale, the Body Image Quality of Life Inventory, Neurotoxicity Rating Scale, the Profile of Mood States, and a five-item quality of life measure.
resultsOne hundred five patients completed the surveys. Forty-eight point four percent of patients experienced one or more moderate-to-severe systemic symptom. The frequency of individual symptoms was between 20% and 56% with almost half of patients rating symptoms as moderate-to-severe in intensity. Low and high systemic symptom burden populations were identified. Previously undescribed chronic neuropsychiatric symptoms were also found to be frequent and severe. The vigor score on the POMS was low. Body image was not adversely impacted. At least 40% of HNC survivors have diminished quality of life, and up to 15% have a poor quality of life.
conclusionsCSS are common among HNC survivors and are frequently moderate to severe in intensity. Of note, previously underrecognized neuropsychiatric symptoms were endorsed by a significant cohort of patients warranting further study. Quality of life was diminished in a significant cohort.
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