Evidence map›Paper›PMID 30554268›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2019

Increased choroidal thickness: a new feature to monitor age-related macular degeneration recurrence.

Victor Bouteleux, Laurent Kodjikian, Maud Mendes, Emilie Agard, Zaïnab Machkour-Bentaleb, Hussam El-Chehab, Philippe Denis, Thibaud Mathis, Corinne Dot

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Observational
  2. Observational
  3. Impact of Brightness on Choroidal Vascularity Index.Journal of clinical medicine · 2024
    Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Victor BouteleuxHôpital d'Instruction des Armées Desgenettes, 108 Boulevard Pinel, 69003, Lyon, France. victorbouteleux@hotmail.fr.ORCID http://orcid.org/0000-0002-5487-6804
Laurent KodjikianHôpital de la Croix-Rousse - HCL, 103 Grande rue de la Croix Rousse, 69004, Lyon, France.
Maud MendesHôpital d'Instruction des Armées Desgenettes, 108 Boulevard Pinel, 69003, Lyon, France.
Emilie AgardHôpital d'Instruction des Armées Desgenettes, 108 Boulevard Pinel, 69003, Lyon, France.
Zaïnab Machkour-BentalebHôpital de la Croix-Rousse - HCL, 103 Grande rue de la Croix Rousse, 69004, Lyon, France.
Hussam El-ChehabHôpital de la Croix-Rousse - HCL, 103 Grande rue de la Croix Rousse, 69004, Lyon, France.
Philippe DenisHôpital de la Croix-Rousse - HCL, 103 Grande rue de la Croix Rousse, 69004, Lyon, France.
Thibaud MathisHôpital de la Croix-Rousse - HCL, 103 Grande rue de la Croix Rousse, 69004, Lyon, France.
Corinne DotHôpital d'Instruction des Armées Desgenettes, 108 Boulevard Pinel, 69003, Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe main objective of this study was to assess choroidal thickness (CT) changes during an exudative recurrence of age-related macular degeneration (AMD).

methodsA real-life prospective non-interventional 9-month study was conducted in two centers in consecutive patients with exudative AMD between November 2016 and July 2017. CT was measured manually in both eyes based on enhanced-depth imaging spectral-domain optical coherence tomography at different follow-up visits scheduled in the morning.

resultsA total of 134 patients were included. Ninety-five patients presented at least one episode, defined by a follow-up visit under controlled condition (dry retina) followed by a visit for exudative recurrence. A total of 119 episodes were analyzed. The mean CT change in the treated eye was + 8.45 ± 13.52 μm (p < 0.001) and + 5.62 ± 14.77 μm (p = 0.009) respectively in the subfoveal area and nasal area. No significant change in CT was observed in the fellow eye. No significant association between CT changes and treatment, number of intravitreal injections, and blood pressure was observed.

conclusionCT increased in case of exudative recurrence of neovascular AMD. The increase was mild but significant. Thus, CT could be used as a monitoring criterion, like the central retinal thickness, in AMD management.

Indexed as

AgedAged, 80 and overAngiogenesis InhibitorsChoroidFemaleFluorescein AngiographyFollow-Up StudiesHumansIntravitreal InjectionsMaleOrgan SizeProspective StudiesRecurrenceTomography, Optical CoherenceVascular Endothelial Growth Factor AWet Macular DegenerationAngiogenesis InhibitorsVascular Endothelial Growth Factor AVEGFA protein, humanChoroidal thicknessEnhanced-depth imagingExudative recurrenceIntravitreal injectionNeovascular AMD

Identifiers

PMID30554268

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.