Evidence map›Paper›PMID 30554040›Full record

SynthesisMultiple sclerosis and related disorders2019

Long-term disability in neuromyelitis optica spectrum disorder with a history of myelitis is associated with age at onset, delay in diagnosis/preventive treatment, MRI lesion length and presence of symptomatic brain lesions.

Maureen A Mealy, Sarah E Mossburg, Su-Hyun Kim, Silvia Messina, Nadja Borisow, Reydmar Lopez-Gonzalez, Juan Pablo Ospina, Michael Scheel, Anusha K Yeshokumar, Amine Awad and 6 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Multiple sclerosis and related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 71 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Clinical features and visual prognosis of very late-onset neuromyelitis optica spectrum disorder-related optic neuritis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 5 countries.

Maureen A MealyJohns Hopkins University, School of Medicine, Department of Neurology, Baltimore, MD, USA; Johns Hopkins University School of Nursing, Baltimore, MD, USA. Electronic address: mmealy1@jhmi.edu.
Sarah E MossburgJohns Hopkins University School of Nursing, Baltimore, MD, USA.
Su-Hyun KimDepartment of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, South Korea.
Silvia MessinaNuffield Department of Clinical Neurosciences, West Wing, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Nadja BorisowCharité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Clinical Research Center and Department of Neurology, Berlin, Germany; Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Reydmar Lopez-GonzalezUniversity of Antioquia, Department of Neurology, Neuroclinica, Medellín, CO, Colombia.
Juan Pablo OspinaJohns Hopkins University, School of Medicine, Department of Neurology, Baltimore, MD, USA.
Michael ScheelCharité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Clinical Research Center and Department of Neurology, Berlin, Germany; Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Anusha K YeshokumarJohns Hopkins University, School of Medicine, Department of Neurology, Baltimore, MD, USA; Icahn School of Medicine at Mount Sinai, Department of Neurology, New York, NY.
Amine AwadNuffield Department of Clinical Neurosciences, West Wing, John Radcliffe Hospital, University of Oxford, Oxford, UK.
M Isabel LeiteNuffield Department of Clinical Neurosciences, West Wing, John Radcliffe Hospital, University of Oxford, Oxford, UK.
JorgeA Jimenez ArangoUniversity of Antioquia, Department of Neurology, Neuroclinica, Medellín, CO, Colombia.
Friedemann PaulCharité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Clinical Research Center and Department of Neurology, Berlin, Germany; Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Jacqueline PalaceNuffield Department of Clinical Neurosciences, West Wing, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Ho Jin KimDepartment of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, South Korea.
Michael LevyJohns Hopkins University, School of Medicine, Department of Neurology, Baltimore, MD, USA.
Johns Hopkins University · USJohn Radcliffe Hospital · GBMax Delbrück Center · DENational Cancer Center · KRUniversidad de Antioquia · CO

Funding

immunopathogenesis of NMO-IgG and AQP4-specific T cells in neuromyelitis opticaK08NS078555 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LEVY, MICHAEL · 2013 to 2017
$965k
NINDS NIH HHS K08 NS078555
6 · The paper itself

Abstract

backgroundNeuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system (CNS) that preferentially targets the spinal cord and optic nerves. Increasing disability is accrued with each inflammatory attack. Disability has been shown to be an independent predictor of poor quality of life in those with NMOSD. Factors associated with increasing disability need further systematic investigation.

methodsWe performed a multi-center retrospective chart analysis of aquaporin-4 (AQP4) seropositive NMOSD patients with a history of myelitis seen at five large referral centers for patients with NMOSD worldwide for whom thorough records including relapse history and corresponding imaging were available. Potential contributors to long-term disability were extracted including demographics, radiographic findings, and clinical characteristics. Multivariable regression modeling was conducted to determine correlates of disability in patients with NMOSD, as measured by the Expanded Disability Status Scale (EDSS).

resultsOne hundred eighty-two AQP4 seropositive patients (88% female) were included in this analysis. Multiple regression modeling revealed that older age at disease onset, delay in diagnosis/preventive treatment, length of longest acute myelitis lesion and presence of symptomatic brain/brainstem lesions were associated with increased disability when holding other variables constant.

conclusionWhile age at onset is a factor that cannot be controlled in NMOSD, we can reduce the delay in diagnosis/preventive treatment and reduce future relapses in the brain/brainstem and spinal cord. Delay in diagnosis/preventive treatment and imaging variables that contributed to increased disability support the need for improved measures for early, accurate diagnosis and management of NMOSD, and aggressive treatment of acute relapses.

Indexed as

AdultAge of OnsetBrainDelayed DiagnosisDisability EvaluationFemaleHumansMagnetic Resonance ImagingMaleNeuromyelitis OpticaRetrospective StudiesRisk FactorsTime FactorsTime-to-TreatmentDevic'sDisabilityEDSSMRINMOSD

Identifiers

PMID30554040
PMCPMC6397677
OpenAlexW2903616728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.