Evidence map›Paper›PMID 30553592›Full record

ArticleThe Journal of thoracic and cardiovascular surgery2019

Late outcomes of strategic arch resection in acute type A aortic dissection.

Bo Yang, Elizabeth L Norton, Terry Shih, Linda Farhat, Xiaoting Wu, Whitney E Hornsby, Karen M Kim, Himanshu J Patel, G Michael Deeb

Open access · bronzeAbstract readComparative StudyVideo-Audio Media
In one paragraph

Article in The Journal of thoracic and cardiovascular surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
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  3. Hybrid repair versus conventional open repair for aortic arch dissection.The Cochrane database of systematic reviews · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Bo YangDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich. Electronic address: boya@med.umich.edu.
Elizabeth L NortonCreighton University School of Medicine, Omaha, Neb.
Terry ShihDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Linda FarhatDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Xiaoting WuDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Whitney E HornsbyDepartment of Internal Medicine, Michigan Medicine, Ann Arbor, Mich.
Karen M KimDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Himanshu J PatelDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
G Michael DeebDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Michigan Medicine · USCreighton University · US

Funding

Define the mechanisms of aortopathy in bicuspid aortic valve patientsR01HL141891 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YANG, BO · 2018 to 2022
$3.5M
Effect of mutations in the TGF-beta pathway genes on smooth muscle cell differentiation using patient derived iPSCs.K08HL130614 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YANG, BO · 2016 to 2020
$848k
NHLBI NIH HHS K08 HL130614NHLBI NIH HHS R01 HL141891
6 · The paper itself

Abstract

objectiveTo compare perioperative and long-term outcomes in patients undergoing hemiarch and aggressive arch replacement for acute type A aortic dissection (ATAAD).

methodsFrom 1996 to 2017, we compared outcomes of hemiarch (n = 322) versus aggressive arch replacements (zones 2 and 3 arch replacement with implantation of 2-4 arch branches, n = 150) in ATAAD. Indications for aggressive arch were arch aneurysm >4 cm or intimal tear in the aortic arch that was not resectable by hemiarch replacement, or dissection of arch branches with malperfusion.

resultsPatients in the aggressive arch group were significantly younger (mean age: 57 vs 61 years old) and had significantly longer hypothermic circulatory arrest, cardiopulmonary bypass, and aortic crossclamp times. There were no significant differences in perioperative outcomes between hemiarch and aggressive arch groups, including 30-day mortality (5.3% vs 7.3%, P = .38) and postoperative stroke rate (7% vs 7%, P = .96). Over 15 years, Kaplan-Meier survival was similar between hemiarch and aggressive arch groups (log-rank P = .55, 10-year survival 70% vs 72%). Given death as a competing factor, incidence rates of reoperation over 15 years (2.1% vs 2.0% per year, P = 1) and 10-year cumulative incidence of reoperation (14% vs 12%, P = .89) for arch and distal aorta pathology were similar between the 2 groups.

conclusionsBoth hemiarch and aggressive arch replacement are appropriate approaches for select patients with ATAAD. Aggressive arch replacement should be considered for an arch aneurysm >4 cm or an intimal tear at the arch unable to be resected by hemiarch replacement, or dissection of the arch branches with malperfusion.

Indexed as

Blood Vessel Prosthesis ImplantationAcute DiseaseAortic Aneurysm, ThoracicAortic DissectionFemaleHumansMaleMiddle AgedPostoperative ComplicationsReoperationRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment Outcomeacute type A aortic dissectionaortic arch surgeryaortic dissectionlong-term outcometotal arch replacement

Identifiers

PMID30553592
PMCPMC6441394
OpenAlexW2901425401

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.