ArticleChemosphere2019
Differential exposure to organophosphate flame retardants in mother-child pairs.
Article in Chemosphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- A systematic review of the use of silicone wristbands for environmental exposure assessment, with a focus on polycyclic aromatic hydrocarbons (PAHs).Journal of exposure science & environmental epidemiology · 2022Pooled it
- Sex-specific disruption of estrogen receptor alpha (ERα) density in the social brain neural network by Firemaster 550.Journal of the Endocrine Society · 2026Article
- Organophosphate ester flame retardants and plasticizers in house dust and Child Behavior Checklist outcomes: A nested study in the Canadian CHILD Birth Cohort.Journal of exposure science & environmental epidemiology · 2026Article
- Silicone Wristbands for Measuring Human Exposure to Organic Chemicals: Uses and Benefits for Human Biological Research.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Measuring the exposome: a practical guide for using wearable passive samplers to assess environmental influences.Exposome · 2026Article
- Silicone Ankle Bands as a Tool to Assess Infant Exposures to Semivolatile Organic Chemicals in Indoor Environments.Environmental science & technology letters · 2025Article
- Mechanisms of Flame Retardant Toxicity and Their Impacts on Anxiety and Cognition in the Brain.Endocrinology · 2025Review
- An Assessment of Multipollutant Exposures Using Silicone Wristbands Among Bangladeshi Youth.International journal of environmental research and public health · 2024Article
- Children's exposure to brominated flame retardants in the home: The TESIE study.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Article
- Patterns of urinary organophosphate ester metabolite trajectories in children: the HOME Study.Journal of exposure science & environmental epidemiology · 2024Article
- Uncovering the common factors of chemical exposure and behavior: Evaluating behavioral effects across a testing battery using factor analysis.Neurotoxicology · 2023Article
- Article
- Gestational exposure to FireMaster® 550 (FM 550) disrupts the placenta-brain axis in a socially monogamous rodent species, the prairie vole (Microtus ochrogaster).Molecular and cellular endocrinology · 2023Article
- Article
- Wearable Passive Samplers for Assessing Environmental Exposure to Organic Chemicals: Current Approaches and Future Directions.Current environmental health reports · 2023Review
- Maternal organophosphate flame retardant exposure alters the developing mesencephalic dopamine system in fetal rat.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Hormone receptor activities of complex mixtures of known and suspect chemicals in personal silicone wristband samplers worn in office buildings.Chemosphere · 2023Article
- Determinants of exposure to endocrine disruptors following hurricane Harvey.Environmental research · 2023Article
- Impacts of Gestational FireMaster 550 Exposure on the Neonatal Cortex Are Sex Specific and Largely Attributable to the Organophosphate Esters.Neuroendocrinology · 2023Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundHumans are ubiquitously exposed to flame retardants, including organophosphate esters (OPEs), through direct contact with consumer products or exposure through household dust. Children are at increased risk because of their proximity to dust, hand-to-mouth activity, and the importance of childhood as a critical period in neurodevelopment.
objectivesTo quantify differences in exposure levels between mothers and children (three to six years of age), we analyzed urinary metabolites of OPEs. We additionally assessed the ability of silicone wristbands (measuring ambient exposure) to predict urinary metabolite concentrations.
methodsWe selected 32 mother and child dyads from an existing cohort. Participants provided baseline urine samples and wore wristbands for one week. After the first week, they returned their wristbands and provided a second urine sample. During the second week, participants wore a second wristband that they returned at the end of week two with a third and final urine sample.
resultsWe found significantly higher levels of bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) (p < 0.001) and lower levels of bis(1-chloro-2-isopropyl) 1-hydroxy-2-propyl phosphate (BCIPHIPP) (p < 0.001) in children's urine samples compared to mothers' samples at baseline. We found that triphenylphosphate (TPHP), tris(1,3-dichloroisopropyl) phosphate (TDCIPP), and tris(1-chloro-2-propyl) phosphate (TCIPP) measured in wristbands predicted their respective metabolite levels in urine.
conclusionChildren had higher levels than mothers for two of six flame retardant metabolites measured in urine. Generally, wristband measurements positively predicted internal dose. As little is known about the health effects of OPEs on child development, future research is needed to determine the impact of differential exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.