ReviewFrontiers in neuroendocrinology2019
Pathophysiological mechanisms implicated in postpartum depression.
Review in Frontiers in neuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06390540 (The Effect of Mobile-Based Exercise Application in the Postpartum Period on Depressive Symptoms, Maternal Attachment and Baby Crying), which is not on this map. Cited by 205 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Mobile-Based Exercise Application in the Postpartum Period on Depressive Symptoms, Maternal Attachment and Baby Crying: A Randomized Controlled Study
Who cites it
205 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Prevalence of postpartum depression in the COVID-19 pandemic and associated factors: systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Which exercise strategies improve postpartum depression? A systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2026Pooled it
- Neural correlates of peripartum depression: a systematic review, meta-analysis and comparison to major depressive disorder.Molecular psychiatry · 2025Pooled it
- Adverse Maternal and Fetal Outcomes Associated with Insomnia During Pregnancy: a Systematic Review and Meta-Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2025Pooled it
- Identification of risk loci for postpartum depression in a genome-wide association study.Psychiatry and clinical neurosciences · 2024Pooled it
- Endocannabinoid levels in female-sexed individuals with diagnosed depression: a systematic review.BMC women's health · 2024Pooled it
- Meta-analysis of association between caesarean section and postpartum depression risk.Frontiers in psychiatry · 2024Pooled it
- Does insomnia treatment prevent depression?Sleep · 2023Pooled it
- Psychological health status in postpartum women during COVID-19 pandemic: A systematic review and meta-analysis.Journal of affective disorders · 2022Pooled it
- Reliability of Evidence to Guide Decision-Making in the Use of Acupuncture for Postpartum Depression.Frontiers in public health · 2022Pooled it
- Midwife-led psychosocial counseling with family support on postpartum depression and maternal functioning: a randomized controlled trial.BMC pregnancy and childbirth · 2025Trial
- Effect of esketamine on serum neurotransmitters in patients with postpartum depression: a randomized controlled trial.BMC anesthesiology · 2024Trial
- Perioperative Adjunctive Esketamine for Postpartum Depression Among Women Undergoing Elective Cesarean Delivery: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Trial
- Beneficial Effects ofNutrients · 2023Trial
- Effect of Acupoint Hot Compress on Postpartum Urinary Retention After Vaginal Delivery: A Randomized Clinical Trial.JAMA network open · 2022Trial
- The Effect of Skin-to-Skin Contact on Postoperative Depression and Physical Recovery of Parturients after Cesarean Section in Obstetrics and Gynecology Department.Computational and mathematical methods in medicine · 2022Trial
- Adoption and Safety Evaluation of Comfortable Nursing by Mobile Internet of Things in Pediatric Outpatient Sedation.Computational and mathematical methods in medicine · 2022Trial
- Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial.JAMA psychiatry · 2021Trial
- Cardiovascular health and depression among postpartum women in the United States.American journal of preventive cardiology · 2026Article
145 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
This review aims to summarize the diverse proposed pathophysiological mechanisms contributing to postpartum depression, highlighting both clinical and basic science research findings. The risk factors for developing postpartum depression are discussed, which may provide insight into potential neurobiological underpinnings. The evidence supporting a role for neuroendocrine changes, neuroinflammation, neurotransmitter alterations, circuit dysfunction, and the involvement of genetics and epigenetics in the pathophysiology of postpartum depression are discussed. This review integrates clinical and preclinical findings and highlights the diversity in the patient population, in which numerous pathophysiological changes may contribute to this disorder. Finally, we attempt to integrate these findings to understand how diverse neurobiological changes may contribute to a common pathological phenotype. This review is meant to serve as a comprehensive resource reviewing the proposed pathophysiological mechanisms underlying postpartum depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.