Evidence map›Paper›PMID 30552890›Full record

ArticleAmerican journal of ophthalmology2019

Association of Age-related Macular Degeneration With Mortality in Patients With Acquired Immunodeficiency Syndrome; Role of Systemic Inflammation.

Douglas A Jabs, Mark L Van Natta, Garrett Trang, Norman G Jones, Jeffrey M Milush, Ryan Cheu, Nichole R Klatt, Ronald P Danis, Peter W Hunt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Douglas A JabsDepartment of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. Electronic address: douglas.jabs@mssm.edu.
Mark L Van NattaDepartment of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Garrett TrangDepartment of Medicine, University of California, San Francisco, School of Medicine, San Francisco, California, USA.
Norman G JonesDepartment of Medicine, University of California, San Francisco, School of Medicine, San Francisco, California, USA.
Jeffrey M MilushDepartment of Medicine, University of California, San Francisco, School of Medicine, San Francisco, California, USA.
Ryan CheuDepartment of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Nichole R KlattDepartment of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Ronald P DanisDepartment of Ophthalmology and Visual Sciences, School of Medicine and Public Health, The University of Wisconsin, Madison, Madison, Wisconsin, USA.
Peter W HuntDepartment of Medicine, University of California, San Francisco, School of Medicine, San Francisco, California, USA.
University of California, San Francisco · USJohns Hopkins University · USUniversity of Miami · USUniversity of Washington · USUniversity of Wisconsin–Madison · US

Funding

Immunologic Determinants of Age-Related Macular Degeneration (AMD)R01EY025093 · NEI · JOHNS HOPKINS UNIVERSITY · PI JABS, DOUGLAS A · 2016 to 2024
$3.4M
NEI NIH HHS R01 EY025093
6 · The paper itself

Abstract

purposeTo evaluate the relationships among age-related macular degeneration (AMD), mortality, and biomarkers of systemic inflammation in patients with acquired immunodeficiency syndrome (AIDS).

designCase-control study.

methodsIn participants with intermediate-stage AMD at enrollment in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) and 2:1 controls matched for age and sex, cryopreserved baseline plasma specimens were assayed for biomarkers of inflammation, including high-sensitivity C-reactive protein (CRP), interleukin (IL)-6, interferon-γ inducible protein (IP)-10, soluble CD14 (sCD14), soluble CD163 (sCD163), kynurenine/tryptophan (KT) ratio, and intestinal fatty acid binding protein (I-FABP). Main outcome measure was mortality.

resultsThe study included 189 patients with AMD and 385 controls. In the unadjusted analysis, AMD was associated with mortality (hazard ratio [HR] 1.48; 95% confidence interval [CI] 1.02, 2.15; P = .04). In an adjusted analysis, CRP (HR 1.36; 95% CI 1.08, 1.71; P = .009), IL-6 (HR 1.45; 95% CI 1.11, 1.90; P = .006), and IP-10 (HR 1.41; 95% CI 1.08, 1.84; P = .01) were associated with mortality. In a Cox regression analysis adjusted for human immunodeficiency virus load, blood CD4+ T cell level, CRP, IL-6, and IP-10, the association of AMD with mortality was attenuated (HR 1.08; 95% CI 0.73, 1.59; P = .70), primarily by the addition of the inflammatory biomarkers.

conclusionsThese data suggest that the increased mortality observed in patients with AIDS with AMD is, at least in part, a result of systemic inflammation.

Indexed as

Acquired Immunodeficiency SyndromeAdultAntigens, CDBiomarkersCase-Control StudiesChemokine CXCL10C-Reactive ProteinFemaleHumansInflammationInterleukin-6KynurenineLongitudinal StudiesMacular DegenerationMaleMiddle AgedAntigens, CDBiomarkersChemokine CXCL10C-Reactive ProteinCXCL10 protein, humanIL6 protein, humanInterleukin-6KynurenineTryptophan

Identifiers

PMID30552890
PMCPMC6639058
OpenAlexW2903683267

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.