Evidence map›Paper›PMID 30552609›Full record

ArticleBiological trace element research2019

Tissue Concentrations of Zinc, Iron, Copper, and Magnesium During the Phases of Full Thickness Wound Healing in a Rodent Model.

Vincent Coger, Nina Million, Christoph Rehbock, Bernd Sures, Milen Nachev, Stephan Barcikowski, Nina Wistuba, Sarah Strauß, Peter M Vogt

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological trace element research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Vincent CogerDepartment of Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany. coger.vincent@mh-hannover.de.ORCID http://orcid.org/0000-0003-1923-4336
Nina MillionTechnical Chemistry I and Center for Nanointegration Duisburg-Essen, University of Duisburg-Essen, Duisburg, Germany.
Christoph RehbockTechnical Chemistry I and Center for Nanointegration Duisburg-Essen, University of Duisburg-Essen, Duisburg, Germany.
Bernd SuresAquatic Ecology and Centre for Water and Environmental Research (ZWU), University of Duisburg-Essen, Essen, Germany.
Milen NachevAquatic Ecology and Centre for Water and Environmental Research (ZWU), University of Duisburg-Essen, Essen, Germany.
Stephan BarcikowskiTechnical Chemistry I and Center for Nanointegration Duisburg-Essen, University of Duisburg-Essen, Duisburg, Germany.
Nina WistubaDepartment of Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany.
Sarah StraußDepartment of Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany.
Peter M VogtDepartment of Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany.
University of Duisburg-Essen · DEMedizinische Hochschule Hannover · DE

Funding

Deutsche Forschungsgemeinschaft Schwerpunktprogramm 1327
6 · The paper itself

Abstract

Wound healing is a complex orchestration of processes involving cell proliferation, migration, differentiation, anabolism, and catabolism in order to restore skin continuity. Within these processes, elements such as metallic ions are involved due to their implications in cell behavior and enzymatic activity regulation. This study analyzed the kinetics of zinc, iron, copper and magnesium concentrations in a full thickness open wound rat model over 14 days. We made wounds with a diameter of 6 mm on the back of Lewis rats and let them heal naturally prior to analysis by histology and inductively coupled plasma mass spectrometry analysis. Histological and immunofluorescence analysis confirmed an inflammation phase until 7 days, epithelial proliferation phase from 16 h to 10 days, and remodeling phase from 7 days onward. These defined phases were correlated with the measured metal element kinetics. Zinc concentrations showed an inverted parabolic progression between 30.4 and a maximum of 39.9 μg/g dry weight. Magnesium values had a similar pattern between 283 and 499 μg/g dry weight. Copper concentrations, on the other hand, followed an inverted sigmoid trend with a decrease from 9.8 to 1.5 μg/g dry weight. Iron had a slight decrease in concentration for 24 h followed by an increase to a maximum of 466 μg/g dry weight. In conclusion, zinc, iron, and copper, even though differing in their total mass within the wound, exhibited concentration curve transitions at day 3. Interestingly, this time point correlates with the maximum proliferating keratinocyte rate during the proliferation phase.

Indexed as

Wound HealingAnimalsCopperDisease Models, AnimalIronMagnesiumMaleRatsRats, Inbred LewWounds and InjuriesZincCopperIronMagnesiumZincCopperIronMagnesiumMetalSkin wound healingZinc

Identifiers

PMID30552609
PMCPMC6656798
OpenAlexW2903699334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.