Trial reportClinical oral investigations2019
Efficacy of Endo-Ice followed by intrapulpal ice application as an adjunct to inferior alveolar nerve block in patients with symptomatic irreversible pulpitis-a randomized controlled trial.
Trial report in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Pharmacological Management of Anxiety on Pain Occurrence During Root Canal Treatment: A Systematic Review.European endodontic journal · 2023Pooled it
- Needle Gauge Influences Pain Perception During Intrapulpal Anaesthesia - A Randomized Clinical Trial.European endodontic journal · 2020Trial
- Comparative Evaluation of the Effectiveness of Intrapulpal Crushed Ice and Intrapulpal Local Anesthesia during Pulpectomy in Primary Molars.International journal of clinical pediatric dentistry · 2026Article
- Pain Management in Mandibular Molars With Symptomatic Irreversible Pulpitis: Mechanisms, Clinical Efficacy and Current Evidence: A Narrative Review.Pain research & management · 2026Review
- Efficacy of ethyl chloride topical anesthesia application on pain perception during intra-oral injections in children compared to benzocaine gel-a single-blind randomized controlled trial.Frontiers in dental medicine · 2026Article
- Review
- Article
- Cryotherapy as a supplementary aid to inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: A randomized controlled trial.Medicine internationalArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of the present study was to evaluate the effect of Endo-Ice followed by intrapulpal ice application for reducing pain during pulp extirpation in mandibular molars with symptomatic irreversible pulpitis. MATERIALS AND
methodsSixty patients diagnosed with symptomatic irreversible pulpitis participated in the present study. Subjects were randomly allocated to any one of the following groups: control group-inferior alveolar nerve block with lignocaine (2%) adrenaline (1:80000), articaine group-inferior alveolar nerve block with lignocaine (2%) adrenaline (1:80000) + Buccal infiltration with articaine (4%) with adrenaline (1:100000); or cold group-inferior alveolar nerve block with lignocaine (2%) adrenaline (1:80000) + cold application. The outcome assessor measured the level of pain during access opening and pulp extirpation using the visual analogue scale. The anxiety level of the patient was also measured.
resultsDuring access opening, there was a significant difference in the pain reduction in the articaine group when compared to cold and control group (p value = 0.02). During pulp extirpation, cold group and articaine group showed a significant reduction in pain levels as compared to the control group (p value = 0.001). There was no difference in the pain level during pulp extirpation among the two test arms (articaine and cold) (p value = 0.99). Further, cold significantly reduced the level of anxiety when compared to the articaine or control group (p value = 0.001).
conclusionHence, cold is a simple, supplementary technique in reducing pain during pulp extirpation. CLINICAL RELEVANCE: Application of cold may help in minimizing the fear of additional injection in managing pain during endodontic treatment.
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