Evidence map›Paper›PMID 30552556›Full record

ArticleSleep & breathing = Schlaf & Atmung2019

Severity of obstructive sleep apnea and extension of coronary artery disease.

Silveria J Rivera-Pérez, Denis Martinez, Gustavo N Araujo, Sandro C Goncalves, Laura K Lazzaretti, Rodrigo V Wainstein, Marco V Wainstein, Jorge P Ribeiro

Abstract read
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. New Modifiable Risk Factors Influencing Coronary Artery Disease Severity.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Silveria J Rivera-PérezSchool of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Denis MartinezSchool of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Gustavo N AraujoSchool of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. gustavon.araujo@gmail.com.ORCID http://orcid.org/0000-0002-1989-1670
Sandro C GoncalvesDivision of Cardiology, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos 2350, Porto Alegre, RS, 90035-003, Brazil.
Laura K LazzarettiCollege of Arts and Sciences, University of Miami, Miami, USA.
Rodrigo V WainsteinDivision of Cardiology, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos 2350, Porto Alegre, RS, 90035-003, Brazil.
Marco V WainsteinSchool of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Jorge P RibeiroSchool of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Universidade Federal do Rio Grande do Sul · BRHospital de Clínicas de Porto Alegre · BRFlorida State University · US

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 060653
6 · The paper itself

Abstract

purposeObstructive sleep apnea (OSA) is highly prevalent among patients with coronary artery disease (CAD). The relationship between the severity of OSA and the severity of CAD has not been entirely established. The objective was to explore the type of correlation existent between the apnea-hypopnea index and the Gensini score, which provides granularity in terms of CAD extension and severity, in search of a dose-response relationship.

methodsA cross-sectional study was conducted among patients that underwent cardiac catheterization due to the suspicion of CAD. Coronary lesions were classified according to one's Gensini score. The severity of OSA was determined by the apnea-hypopnea index (AHI), obtainable through a respiratory polysomnography.

resultsEighty patients were eligible for the study. The mean age was 55 years, and 37% had AHI ≥ 15. Forty-four subjects (55%) had a Gensini score of 0, and five had a score < 2, indicating a 25% obstruction in a non-proximal artery; these individuals were considered non-CAD controls; and clinical characteristics were similar between them and CAD cases. Attempts to correlate the AHI with the Gensini score either converting both variables to square root (r = 0.08) or using Spearman's rho (rho = 0.13) obtained small, non-significant coefficients. AHI ≥ 15 was a predictor of a Gensini score ≥ 2 with a large effect size (OR 4.46) when adjusted for age ≥ 55 years, BMI ≥ 25 kg/m

conclusionsIn patients undergoing coronary angiography due to suspected CAD, moderate-severe OSA was associated with the presence of CAD but no significant correlation was found between the lesion severity and the AHI. Our results suggest that OSA influences CAD pathogenesis but a dose-response relationship is unlikely.

Indexed as

Severity of Illness IndexAgedCardiac CatheterizationCoronary AngiographyCoronary Artery DiseaseCross-Sectional StudiesFemaleHumansHypertensionMaleMiddle AgedPolysomnographyRisk FactorsSleep Apnea, ObstructiveAtherosclerosisCardiovascular diseaseCoronary diseaseGensini scoreSleep apnea

Identifiers

PMID30552556
OpenAlexW2903781179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.