Evidence map›Paper›PMID 30552521›Full record

ArticleVirchows Archiv : an international journal of pathology2019

A novel partner of TFE3 in the Xp11 translocation renal cell carcinoma: clinicopathological analyses and detection of EWSR1-TFE3 fusion.

Hironori Fukuda, Ikuma Kato, Mitsuko Furuya, Reiko Tanaka, Toshio Takagi, Tsunenori Kondo, Yoji Nagashima

Abstract readCase Reports
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021
    Guideline
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Genomic alterations and diagnosis of renal cancer.Virchows Archiv : an international journal of pathology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hironori FukudaDepartment of Urology, Tokyo Women's Medical University, Tokyo, Japan.
Ikuma KatoDepartment of Molecular Pathology, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Mitsuko FuruyaDepartment of Molecular Pathology, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan. mfuruya@yokohama-cu.ac.jp.
Reiko TanakaDepartment of Surgical Pathology, Tokyo Women's Medical University, Tokyo, Japan.
Toshio TakagiDepartment of Urology, Tokyo Women's Medical University, Tokyo, Japan.
Tsunenori KondoDepartment of Urology, Tokyo Women's Medical University, Tokyo, Japan.
Yoji NagashimaMedical Mycology Research Center, Chiba University, Chiba, Japan.
Tokyo Women's Medical University · JPYokohama City University · JPChiba University Hospital · JP

Funding

Japan Society for the Promotion of Science 16K19085Japan Society for the Promotion of Science 17K08745Japan Society for the Promotion of Science 17K11162
6 · The paper itself

Abstract

The renal cell carcinomas associated with Xp11 translocations (Xp11 translocation RCCs) harbor gene fusions involving TFE3, a member of the microphthalmia-associated transcription factor (MiTF) family. In the present study, we identified a novel partner of TFE3, Ewing sarcoma breakpoint region 1 (EWSR1), in an Xp11 translocation RCC. A 57-year-old Japanese woman without special disease history was referred to us for treatment of an RCC. The resected tumor displayed an alveolar growth pattern with high-grade nuclei. The tumor was diffusely positive for TFE3 and cathepsin K. Anchored multiplex PCR revealed a novel fusion, EWSR1-TFE3. Fluorescent in situ hybridization analysis demonstrated the rearrangements of EWSR1 and TFE3. RT-PCR analysis confirmed the chimeric transcript. No neoplasm with EWSR1-TFE3 has been reported so far, in any organ. The results will expand the genomic spectrums of Xp11 translocation RCCs and contribute to better understanding of the roles of the MiTF family in the oncogenic process.

Indexed as

Chromosomes, Human, XGene FusionTranslocation, GeneticBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBiomarkers, TumorCarcinoma, Renal CellFemaleGenetic Predisposition to DiseaseHumansImmunohistochemistryIn Situ Hybridization, FluorescenceKidney NeoplasmsMiddle AgedMultiplex Polymerase Chain ReactionNeoplasm GradingPhenotypeBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBiomarkers, TumorEWSR1 protein, humanRNA-Binding Protein EWSTFE3 protein, humanChimeric transcriptEWSR1Microphthalmia-associated transcription factor (MiTF)TFE3Xp11 translocation renal cell carcinoma

Identifiers

PMID30552521
OpenAlexW2905346358

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.