ArticleEuropean radiology2019
Time-series hyperpolarized xenon-129 MRI of lobar lung ventilation of COPD in comparison to V/Q-SPECT/CT and CT.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- TBMJ open respiratory research · 2025Article
- Multivariate metal-organic frameworks enable chemical shift-encoded MRI with femtomolar sensitivity for biological systems.Nature communications · 2025Article
- Evaluation of an integrated variable flip angle protocol to estimate coil BMagnetic resonance in medicine · 2025Article
- Combining hyperpolarizedJournal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarizedEuropean radiology · 2025Article
- UltrasensitiveAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Longitudinal study of COPD phenotypes using integrated SPECT and qCT imaging.Frontiers in physiology · 2025Article
- Long-lived enhanced magnetization-A practical metabolic MRI contrast material.Science advances · 2024Article
- Exploratory Study on COPD Phenotypes and their Progression: Integrating SPECT and qCT Imaging Analysis.medRxiv : the preprint server for health sciences · 2024Article
- HyperpolarizedAcademic radiology · 2024Article
- Voxel-Wise Comparison of Co-Registered Quantitative CT and Hyperpolarised Gas Diffusion-Weighted MRI Measurements in IPF.Diagnostics (Basel, Switzerland) · 2023Article
- PhysVENeT: a physiologically-informed deep learning-based framework for the synthesis of 3D hyperpolarized gas MRI ventilation.Scientific reports · 2023Article
- Gas exchange and ventilation imaging of healthy and COPD subjects using hyperpolarized xenon-129 MRI and a 3D alveolar gas-exchange model.European radiology · 2023Article
- Comparison of ventilation defects quantified by Technegas SPECT and hyperpolarizedFrontiers in physiology · 2023Article
- Quantitative measurements of emphysema in ultra-high resolution computed tomography using model-based iterative reconstruction in comparison to that using hybrid iterative reconstruction.Physical and engineering sciences in medicine · 2022Article
- Pulmonary functional MRI: Detecting the structure-function pathologies that drive asthma symptoms and quality of life.Respirology (Carlton, Vic.) · 2022Review
- Functional lung imaging in thoracic tumor radiotherapy: Application and progress.Frontiers in oncology · 2022Review
- Pixel-based analysis of pulmonary changes on CT lung images due to COVID-19 pneumonia.Journal of clinical imaging science · 2022Article
- Accelerate gas diffusion-weighted MRI for lung morphometry with deep learning.European radiology · 2022Article
- Quantitative CT parameters correlate with lung function in chronic obstructive pulmonary disease: A systematic review and meta-analysis.Frontiers in surgery · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo derive lobar ventilation in patients with chronic obstructive pulmonary disease (COPD) using a rapid time-series hyperpolarized xenon-129 (HPX) magnetic resonance imaging (MRI) technique and compare this to ventilation/perfusion single-photon emission computed tomography (V/Q-SPECT), correlating the results with high-resolution computed tomography (CT) and pulmonary function tests (PFTs). MATERIALS AND
methodsTwelve COPD subjects (GOLD stages I-IV) participated in this study and underwent HPX-MRI, V/Q-SPECT/CT, high-resolution CT, and PFTs. HPX-MRI was performed using a novel time-series spiral k-space sampling approach. Relative percentage ventilations were calculated for individual lobe for comparison to the relative SPECT lobar ventilation and perfusion. The absolute HPX-MRI percentage ventilation in each lobe was compared to the absolute CT percentage emphysema score calculated using a signal threshold method. Pearson's correlation and linear regression tests were performed to compare each imaging modality.
resultsStrong correlations were found between the relative lobar percentage ventilation with HPX-MRI and percentage ventilation SPECT (r = 0.644; p < 0.001) and percentage perfusion SPECT (r = 0.767; p < 0.001). The absolute CT percentage emphysema and HPX percentage ventilation correlation was also statistically significant (r = 0.695, p < 0.001). The whole lung HPX percentage ventilation correlated with the PFT measurements (FEV
conclusionLobar ventilation with HPX-MRI showed a strong correlation with lobar ventilation and perfusion measurements derived from SPECT/CT, and is better than the emphysema score obtained with high-resolution CT. KEY POINTS: • The ventilation hyperpolarized xenon-129 MRI correlates well with ventilation and perfusion with SPECT/CT with the advantage of higher temporal and spatial resolution. • The hyperpolarized xenon-129 MRI correlates with the PFT measurements better than the high-resolution CT with the advantage of avoiding the use of ionizing radiation.
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