ArticlePlant cell reports2019
Mitogen-activated protein kinases MPK3 and MPK6 are required for stem cell maintenance in the Arabidopsis shoot apical meristem.
Article in Plant cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Peptide hormones in shaping root system architecture and environmental adaptation: Current advances and translational perspectives.Plant communications · 2026Review
- Protein Phosphorylation: An Essential Role in Shoot Apical Meristem Homeostasis.Plants (Basel, Switzerland) · 2026Review
- Rare Natural SNP Activates SHOOT APICAL MERISTEM ENLARGER1 to Increase Branch Number and Silique Number on the Main Inflorescence in Brassica napus.Plant biotechnology journal · 2026Article
- The G protein-casein kinase 2 module acts as a pivot in plasma membrane-to-nucleus CLAVATA signaling to control shoot apical meristem size.Nature communications · 2026Article
- MPK3 as a Signalling Hub in Plants: Integrating Plant Growth, Development and Stress Response.Plants (Basel, Switzerland) · 2026Article
- Regulatory layers of robustness of CLAVATA-WUSCHEL feedback system in stem cell homeostasis.Frontiers in plant science · 2026Review
- Modulation of Root Nitrogen Uptake Mechanisms Mediated by Beneficial Soil Microorganisms.Plants (Basel, Switzerland) · 2025Review
- Research Progress of CLE and Its Prospects in Woody Plants.Plants (Basel, Switzerland) · 2025Review
- Salinity survival: molecular mechanisms and adaptive strategies in plants.Frontiers in plant science · 2025Review
- Small Peptides: Orchestrators of Plant Growth and Developmental Processes.International journal of molecular sciences · 2024Review
- Male Germ Cell Specification in Plants.International journal of molecular sciences · 2024Review
- Article
- Stem Cells: Engines of Plant Growth and Development.International journal of molecular sciences · 2023Review
- Restructuring plant types for developing tailor-made crops.Plant biotechnology journal · 2023Review
- Salinity-Triggered Responses in Plant Apical Meristems for Developmental Plasticity.International journal of molecular sciences · 2023Review
- Transcriptomics Using the Enriched Arabidopsis Shoot Apex Reveals Developmental Priming Genes Involved in Plastic Plant Growth under Salt Stress Conditions.Plants (Basel, Switzerland) · 2022Article
- Fine mapping of qDB.A03, a QTL for rapeseed branching, and identification of the candidate gene.Molecular genetics and genomics : MGG · 2022Article
- Receptor-like cytoplasmic kinases PBL34/35/36 are required for CLE peptide-mediated signaling to maintain shoot apical meristem and root apical meristem homeostasis in Arabidopsis.The Plant cell · 2022Article
- Illuminating the molecular mechanisms underlying shoot apical meristem homeostasis in plants.Plant biotechnology (Tokyo, Japan) · 2022Article
- MAP kinase cascades in plant development and immune signaling.EMBO reports · 2022Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
key messageCLV3p-mediated phosphorylation of MPK3 and MPK6 occurs via CLV1 and BAM1 receptors to regulate the maintenance of SAM development. The CLAVATA peptide-receptor (CLV3p-CLV1) pathway modulates a homeodomain master regulator WUSCHEL (WUS) transcription factor in the shoot apical meristem (SAM) with poorly defined signaling mechanisms. Here, we report that mitogen-activated protein kinases (MAPKs, also known as MPKs in plants) act in an intracellular signaling cascade to play an important role in the maintenance of SAM development. Interestingly, the application of exogenous CLV3p triggers rapid signaling in the SAM via dynamic activation of MPK3 and MPK6, which are positively regulated by both CLV1 and BARELY ANY MERISTEM 1 (BAM1) receptors. Surprisingly, the timing of MAPK activation is tightly correlated with the transcriptional repression of WUS expression in the SAM, indicating a fast CLV3p-CLV1/BAM1 signaling event. Furthermore, conditional mpk3,6 double mutants exhibited CLV3p insensitivity in stem cell maintenance manifested by the persistent SAM growth in the presence of exogenous CLV3p signals, as well as elevated WUS expression and repressed WUS-specific target genes. Taken together, these results suggest that MPK3 and MPK6 activated by CLV3p signals through mainly CLV1 and BAM1 receptors are key regulators controlling stem cell homeostasis in the SAM.
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