ArticleScientific reports2018
Comparative metabolomics of scab-resistant and susceptible apple cell cultures in response to scab fungus elicitor treatment.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Comparative metabolomics of resistant and susceptible pecan leaflets uncovers early defense responses to scab infection.BMC plant biology · 2026Article
- Enhanced scab resistance in apple conferred by Rvi6 and polyploidy is linked with distinct shifts in the phenolics profile.Scientific reports · 2025Article
- Molecular Insights into the Temperature-Dependent Binding and Conformational Dynamics of Noraucuparin with Bovine Serum Albumin: A Microsecond-Scale MD Simulation Study.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Enhancement of Apple Stress Resistance via Proline Elevation by Sugar Substitutes.International journal of molecular sciences · 2024Article
- Phenotyping, genetics, and "-omics" approaches to unravel and introgress enhanced resistance against apple scab (Horticulture research · 2024Article
- Rowanberry-A Source of Bioactive Compounds and Their Biopharmaceutical Properties.Plants (Basel, Switzerland) · 2023Review
- Biphenyls and dibenzofurans of the rosaceous subtribe Malinae and their role as phytoalexins.Planta · 2023Review
- Formulated hydroxy fatty acids from fruit pomaces reduce apple scab development caused byFrontiers in plant science · 2023Article
- Simultaneous removal of arsenic, fluoride, and manganese from synthetic wastewater by Vetiveria zizanioides.Environmental science and pollution research international · 2021Article
- Benzoate-CoA ligase contributes to the biosynthesis of biphenyl phytoalexins in elicitor-treated pear cell cultures.Plant cell reports · 2020Article
- Advances of Metabolomics in Fungal Pathogen-Plant Interactions.Metabolites · 2019Review
- Elucidating genetic variability and population structure in Venturia inaequalis associated with apple scab diseaseusing SSR markers.PloS one · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Apple scab disease caused by the fungus Venturia inaequalis is a devastating disease that seriously affects quality and yield of apples. In order to understand the mechanisms involved in scab resistance, we performed gas chromatography-mass spectrometry based metabolomics analysis of the cell culture of scab resistant cultivar 'Florina' and scab susceptible cultivar 'Vista Bella' both prior -to and -following treatment with V. inaequalis elicitor (VIE). A total 21 metabolites were identified to be altered significantly in 'Florina' cell cultures upon VIE-treatment. Among 21 metabolites, formation of three new specialized metabolites aucuparin, noraucuparin and eriobofuran were observed only in resistant cultivar 'Florina' after the elicitor treatment. The score plots of principal component analysis (PCA) exhibited clear discrimination between untreated and VIE-treated samples. The alteration in metabolite levels correlated well with the changes in the transcript levels of selected secondary metabolite biosynthesis genes. Aucuparin, noraucuparin and eriobofuran isolated from the 'Florina' cultures showed significant inhibitory effect on the conidial germination of V. inaequalis. The results expand our understanding of the metabolic basis of scab-resistance in apple and therefore are of interest in apple breeding programs to fortify scab resistance potential of commercially grown apple cultivars.
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