ArticleScientific reports2018
Miniscule differences between sex chromosomes in the giant genome of a salamander.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Protocol for non-invasive genotyping of axolotls using skin swabbing.STAR protocols · 2026Article
- Linkage Mapping vs. Association: A Comparison of Two RADseq-Based Approaches to Identify Markers for Homomorphic Sex Chromosomes in Large Genomes.Molecular ecology resources · 2025Article
- Development and validation of sex-associated markers using whole-genome re-sequencing in frogFrontiers in genetics · 2025Article
- Age- and dose-dependent susceptibility of axolotls (Ambystoma mexicanum) by bath exposure to Ambystoma tigrinum virus (ATV).Virology · 2023Article
- The use of transgenics in the laboratory axolotl.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Review
- Gene and transgenics nomenclature for the laboratory axolotl-Ambystoma mexicanum.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Sex-related differences in aging rate are associated with sex chromosome system in amphibians.Evolution; international journal of organic evolution · 2022Article
- Review
- Sex chromosomes in meiotic, hemiclonal, clonal and polyploid hybrid vertebrates: along the 'extended speciation continuum'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- A brief review of vertebrate sex evolution with a pledge for integrative research: towards 'Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Large-scale variation in single nucleotide polymorphism density within the laboratory axolotl (Ambystoma mexicanum).Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Comparative genomics ofLife science alliance · 2021Article
- DNA transposon invasion and microsatellite accumulation guide W chromosome differentiation in a Neotropical fish genome.Chromosoma · 2019Article
- Genomic Data Reveal Conserved Female Heterogamety in Giant Salamanders with Gigantic Nuclear Genomes.G3 (Bethesda, Md.) · 2019Article
- Identification of the master sex determining gene in Northern pike (Esox lucius) reveals restricted sex chromosome differentiation.PLoS genetics · 2019Article
- Deciphering the Origin and Evolution of the XInternational journal of molecular sciences · 2019Article
- Shedding Light on a SecretiveGenes · 2019Article
- A chromosome-scale assembly of the axolotl genome.Genome research · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In the Mexican axolotl (Ambystoma mexicanum), sex is determined by a single Mendelian factor, yet its sex chromosomes do not exhibit morphological differentiation typical of many vertebrate taxa that possess a single sex-determining locus. As sex chromosomes are theorized to differentiate rapidly, species with undifferentiated sex chromosomes provide the opportunity to reconstruct early events in sex chromosome evolution. Whole genome sequencing of 48 salamanders, targeted chromosome sequencing and in situ hybridization were used to identify the homomorphic sex chromosome that carries an A. mexicanum sex-determining factor and sequences that are present only on the W chromosome. Altogether, these sequences cover ~300 kb of validated female-specific (W chromosome) sequence, representing ~1/100,000
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.